PMID: 18728913Aug 30, 2008Paper

Follow-up study of cancer incidence after chlorophenol exposure in a community in southern Finland

Scandinavian Journal of Work, Environment & Health
P LampiE Pukkala

Abstract

In the 1970s and 1980s, people in a village in southern Finland had been exposed to high concentrations of chlorophenols in the drinking water and in fish from a nearby lake. An ecological analysis and a case-control study conducted around 1990 indicated significant excess in the incidence of non-Hodgkin's lymphoma and soft-tissue cancer in the municipality and a relationship between the chlorophenol exposure and the incidence of these cancers. The present article reports a follow-up of cancer risk in the same study area during a 20-year period after the closing of the old water intake plant, which was contaminated by chlorophenols. The observed and expected numbers of cancer were obtained for three periods, 1953-1971 (before exposure), 1972-1986 (during exposure) and 1987-2006 (after exposure), for all cancers combined and separately for cancers potentially related to chlorophenols. The present study demonstrates that all of the cancer risks returned to the average population level during the 20-year period after the old water intake plant was closed and chlorophenol exposure stopped. The rapid changes in cancer risk after changes in chlorophenol exposure suggest that chlorophenols may have a promotion effect in the carcinogen...Continue Reading

Citations

Mar 6, 2012·Toxicology Letters·Jouko Tuomisto, Jouni T Tuomisto

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