PMID: 15222589Jun 30, 2004Paper

Following alcohol consumption, nontreatment-seeking alcoholics report greater stimulation but similar sedation compared with social drinkers

Journal of Studies on Alcohol
Suzanne E ThomasRaymond F Anton

Abstract

Drinking behavior, and consequently the risk to develop alcohol problems, is influenced in part by one's subjective response to alcohol. Studies have shown that individuals at risk for alcoholism report greater stimulation, less sedation and/or "low response" to alcohol. Whether this effect exists in early-stage alcoholics has not been examined. The present study was conducted to determine whether alcoholics and social drinkers differ in response following a challenge dose of alcohol in a clinical laboratory procedure. Nontreatment-seeking alcoholics (n = 38) and social drinkers (n = 30) randomized to a placebo in a medication study were given a standard dose of alcohol (0.34 g/kg women; 0.4 g/kg men) in a bar-laboratory setting. Assessments, including blood alcohol concentrations and the Biphasic Alcohol Effects Scale, were conducted four times (from 10 to 60 minutes following initiation of consumption). Alcoholics reported greater stimulation, but similar sedation, compared with social drinkers, following alcohol consumption. This study provides the first evidence of greater stimulation following alcohol in alcoholics not seeking treatment.

Citations

Mar 27, 2009·Alcoholism, Clinical and Experimental Research·Sandra Y RuegerAndrea C King
Jul 23, 2011·Alcoholism, Clinical and Experimental Research·Patrick D Quinn, Kim Fromme
Oct 15, 2013·Alcoholism, Clinical and Experimental Research·Daniel J O RocheAndrea C King
Dec 24, 2009·Alcoholism, Clinical and Experimental Research·Meghan E Morean, William R Corbin
Dec 3, 2009·Alcoholism, Clinical and Experimental Research·David B Newlin, Rachael M Renton
Feb 13, 2010·Addiction Biology·John C CrabbeCindy L Ehlers
Jul 23, 2013·Pharmacology, Biochemistry, and Behavior·Megan L T HilbertWilliam C Griffin
Apr 28, 2016·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Stephen J BoydRaymond F Anton
Apr 12, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sarah W YipRobert D Rogers
Sep 15, 2004·Alcoholism, Clinical and Experimental Research·David J DrobesKonstantin Voronin
Feb 12, 2008·Alcoholism, Clinical and Experimental Research·Henry R KranzlerCheryl Oncken
Jan 18, 2005·Alcoholism, Clinical and Experimental Research·Elizabeth M YoungHarriet de Wit

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