Following disease progression in motor neuron disorders with 3 motor unit number estimation methods

Muscle & Nerve
Anna Bystrup JacobsenH Tankisi

Abstract

The objective of this study was to evaluate a recently developed motor unit number estimation (MUNE) method, MScanFit MUNE (MScan), as a measure of disease progression in amyotrophic lateral sclerosis (ALS) compared with compound muscle action potential (CMAP) amplitude and 2 traditional MUNE methods. ALS patients were evaluated clinically using the ALS Functional Rating Scale-Revised (ALSFRS-R). MScan, multiple-point stimulation MUNE (MPS), and motor unit number index (MUNIX) were performed in the abductor pollicis brevis (APB) muscle at baseline (27 patients), 4 months (23 patients), and 8 months (16 patients). Of the 5 measures, MScan registered the largest decline (8.7% per month), compared with MPS (3.4%), MUNIX (4.8%), CMAP amplitude (2.0%), and ALSFRS-R (1.9%). Only MScan and ALSFRS-R registered significant decrements over 4 and 8 months. MScan may be useful as a sensitive, objective tool for quantifying motor unit loss in ALS. Muscle Nerve 59:82-87, 2019.

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Citations

May 18, 2020·Muscle & Nerve·Ozlem Kesim-SahinAli Emre Oge
Apr 20, 2019·Frontiers in Neurology·Nick S VerberPamela J Shaw
Apr 9, 2020·Frontiers in Neuroscience·Emilio Geijo-BarrientosSalvador Martínez
Jan 16, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Boudewijn T H M SleutjesH Stephan Goedee
Jan 12, 2021·Neurophysiologie clinique = Clinical neurophysiology·Ali Asghar OkhovatFarzad Fatehi
Jul 4, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Christian SchneiderHelmar C Lehmann
Sep 4, 2021·Annals of Clinical and Translational Neurology·Steve VucicUNKNOWN TEALS study group
Dec 3, 2021·Muscle & Nerve·Diederik J L Stikvoort GarcíaBoudewijn T H M Sleutjes
Jan 13, 2022·Muscle & Nerve·Emel Oguz-AkarsuAli Emre Oge

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