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Following spinal cord injury, PDE4B drives an acute, local inflammatory response and a chronic, systemic response exacerbated by gut dysbiosis and endotoxemia

Neurobiology of Disease

Apr 14, 2019

Scott A MyersScott R Whittemore

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Abstract

Emerging evidence links changes in the gut microbiome and intestinal barrier function to alterations in CNS function. We examined the role of endotoxin-responsive, cAMP-specific, Pde4 subfamily b (Pde4b) enzyme in gut dysbiosis induced neuro-inflammation and white matter loss following ...read more

Mentioned in this Paper

Cyclic AMP
Analgesics, Anti-Inflammatory
Astrocytes
Biological Markers
Endoplasmic Reticulum
Endotoxins
Gene Deletion
Glial Fibrillary Acidic Protein
Gram-Negative Bacteria
Inflammation
3
15
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Following spinal cord injury, PDE4B drives an acute, local inflammatory response and a chronic, systemic response exacerbated by gut dysbiosis and endotoxemia

Neurobiology of Disease

Apr 14, 2019

Scott A MyersScott R Whittemore

PMID: 30557659

DOI: 10.1016/j.nbd.2018.12.008

Abstract

Emerging evidence links changes in the gut microbiome and intestinal barrier function to alterations in CNS function. We examined the role of endotoxin-responsive, cAMP-specific, Pde4 subfamily b (Pde4b) enzyme in gut dysbiosis induced neuro-inflammation and white matter loss following ...read more

Mentioned in this Paper

Cyclic AMP
Analgesics, Anti-Inflammatory
Astrocytes
Biological Markers
Endoplasmic Reticulum
3
15

Similar Papers Found In These Feeds

Related Papers

Paper Details
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  • References
  • Citations1
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