Following the electrons: peculiarities in the catalytic cycles of radical SAM enzymes

Natural Product Reports
Mark W RuszczyckyHung-Wen Liu

Abstract

Radical SAM enzymes use S-adenosyl-l-methionine as an oxidant to initiate radical-mediated transformations that would otherwise not be possible with Lewis acid/base chemistry alone. These reactions are either redox neutral or oxidative leading to certain expectations regarding the role of SAM as either a reusable cofactor or the ultimate electron acceptor during each turnover. However, these expectations are frequently not realized resulting in fundamental questions regarding the redox handling and movement of electrons associated with these biological catalysts. Herein we provide a focused perspective on several of these questions and associated hypotheses with an emphasis on recently discovered radical SAM enzymes.

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Citations

Aug 30, 2018·Angewandte Chemie·Christopher T Walsh, Bradley S Moore
Feb 23, 2020·Current Opinion in Chemical Biology·Wei DingQi Zhang
Mar 7, 2021·Journal of Industrial Microbiology & Biotechnology·Yuxuan YeTodd K Hyster
Sep 8, 2021·Journal of the American Chemical Society·Ronald A BesandreHung-Wen Liu
Dec 4, 2021·Natural Product Reports·Suze MaQi Zhang

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