Nov 14, 2019

Food Allergies and Ageing

International Journal of Molecular Sciences
Massimo De MartinisLia Ginaldi

Abstract

All over the world, there is an increase in the overall survival of the population and the number of elderly people. The incidence of allergic reactions is also rising worldwide. Until recently, allergies, and in particular food allergies (FAs), was regarded as a pediatric problem, since some of them start in early childhood and may spontaneously disappear in adulthood. It is being discovered that, on the contrary, these problems are increasingly affecting even the elderly. Along with other diseases that are considered characteristics of advanced age, such as cardiovascular, dysmetabolic, autoimmune, neurodegenerative, and oncological diseases, even FAs are increasingly frequent in the elderly. An FA is a pleiomorphic and multifactorial disease, characterized by an abnormal immune response and an impaired gut barrier function. The elderly exhibit distinct FA phenotypes, and diagnosis is difficult due to frequent co-morbidities and uncertainty in the interpretation of in vitro and in vivo tests. Several factors render the elderly susceptible to FAs, including the physiological changes of aging, a decline in gut barrier function, the skewing of adaptive immunity to a Th2 response, dysregulation of innate immune cells, and age-rel...Continue Reading

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Mentioned in this Paper

In Vivo
Immune Response
Immune Effector Cell
Food
Th2 tyrosine hydroxylase 2, Danio rerio
Dysmetabolic Syndrome
Adaptive Immunity
Autoimmune Diseases
Cytokine
Aging

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