Food allergies and hypersensitivity: a review of pharmacotherapy and therapeutic strategies

Expert Opinion on Pharmacotherapy
Wesley BurksLaurent Pons

Abstract

Food allergy is a major cause of life-threatening hypersensitivity reactions. Food-induced anaphylaxis is the most common reason for someone to present to the emergency department for an anaphylactic reaction. At present, the avoidance of the allergenic food is the only method of preventing further reactions for allergic patients. With better characterization of allergens and an understanding of the immunologic mechanism involved in this reaction, investigators have developed several therapeutic modalities potentially applicable to the treatment and eventual prevention of food allergy. This review identifies and discusses the potential treatment options for food allergy that are under development. Relevant articles are reviewed pertaining to the treatment of food allergy. Among the therapeutic options currently under investigation are anti-IgE therapy, peptide immunotherapy, traditional Chinese medicine, mutated protein immunotherapy, DNA immunization and immunization with immunostimulatory sequences linked to allergens. These novel forms of treatment for allergic disease hold promise for the safe and effective treatment of food-allergic individuals and the prevention of food allergy in the future.

References

Aug 1, 1992·The Journal of Allergy and Clinical Immunology·J J OppenheimerD Y Leung
Aug 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·T J BrinerJ L Greenstein
Dec 1, 1996·American Journal of Respiratory and Critical Care Medicine·P S NormanC F Nicodemus
Jun 1, 1997·The Journal of Allergy and Clinical Immunology·H S NelsonD Leung
Dec 31, 1997·The Journal of Experimental Medicine·R S ChuC V Harding
Nov 21, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R Asero
May 18, 1999·The Journal of Allergy and Clinical Immunology·H A Sampson
Aug 19, 1999·The Journal of Allergy and Clinical Immunology·S J HongD Y Leung
Dec 23, 1999·The New England Journal of Medicine·H MilgromW J Metzger
May 5, 2000·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·R Asero
Jul 11, 2000·The Journal of Allergy and Clinical Immunology·X M LiH A Sampson
Oct 9, 2001·The Journal of Allergy and Clinical Immunology·X M LiH A Sampson
Feb 4, 2003·Alimentary Pharmacology & Therapeutics·G PatriarcaD Schiavino
Feb 20, 2003·The Journal of Allergy and Clinical Immunology·Hugh A Sampson
Mar 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiu-Min LiHugh A Sampson
Mar 15, 2003·The New England Journal of Medicine·Donald Y M LeungUNKNOWN Avon Longitudinal Study of Parents and Children Study Team
Jul 29, 2003·European Journal of Immunology·Miguel A Pérez-MachadoSimon H Murch
Jan 5, 2005·Clinical Reviews in Allergy & Immunology·Wesley BurksGary A Bannon
Jan 8, 2005·The Journal of Allergy and Clinical Immunology·Kamal D SrivastavaXiu-Min Li
Jan 11, 2005·Current Opinion in Allergy and Clinical Immunology·Andrew SaxonChristopher L Kepley
Nov 9, 2005·The Journal of Allergy and Clinical Immunology·Ernesto EnriqueAnna Cisteró-Bahíma
Feb 4, 2006·The Journal of Allergy and Clinical Immunology·Scott H Sicherer, Hugh A Sampson
Jun 24, 2006·Allergy·B NiggemannK Beyer
Jan 9, 2007·The Journal of Allergy and Clinical Immunology·Ariana D BuchananA Wesley Burks
Feb 13, 2007·The Journal of Allergy and Clinical Immunology·Verena NiederbergerRudolf Valenta
Aug 11, 2007·The Journal of Allergy and Clinical Immunology·Scott H Sicherer, Hugh A Sampson

❮ Previous
Next ❯

Citations

Jul 26, 2011·The Proceedings of the Nutrition Society·Sandra Sénéchal, Martin Kussmann
Jul 28, 2012·Allergologia et immunopathologia·V Fuentes-AparicioE Alonso-Lebrero
Jan 17, 2012·Immunology and Allergy Clinics of North America·Julia Ann Wisniewski, Xiu-Min Li
Jul 2, 2009·Current Opinion in Allergy and Clinical Immunology

❮ Previous
Next ❯

Related Concepts

Related Feeds

Ataxia telangiectasia (MDS)

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

Ataxia telangiectasia

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.