Food allergy in mice is modulated through the thymic stromal lymphopoietin pathway

Clinical and Translational Allergy
C P FrossardP A Eigenmann

Abstract

Thymic stromal lymphopoietin (TSLP) is involved in the pathogenesis of allergic reactions in the skin and the lung. Nevertheless, data on the role of TSLP in food allergy are scarce. We explored the role of TSLP in a mouse model with oral sensitization and oral challenge eliciting food allergy. TSLP receptor (TSLPR)-/- mice and wild type mice were orally sensitized to β-lactoglobulin in presence of cholera toxin (CT) or CT alone. The elicited immune response was characterized in vitro and the mice were subsequently challenged with the antigen. Lymphocytes from various locations in the gut were activated either by the antigen or by CT and assayed for cytokine secretion. Here we report that TSLPR-/- are less prone to generate food-induced reactions in conjunction with a decreased antigen-specific IgG1, but not IgE response. In addition, mesenteric lymphnode lymphocytes of TSLPR-/- mice were secreting lower quantities of IL-4, IL-5 and IL-10 after in vivo Ag activation, whereas higher numbers of IL-17 secreting cells were observed. Similarly, activation by the Th2-type adjuvant cholera toxin resulted in an increased frequency of IL-12 and IL-17 secreting lamina propria and mesenteric lymphocytes, together with increased production...Continue Reading

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Citations

Dec 20, 2017·Archivum Immunologiae Et Therapiae Experimentalis·Aziza SaidovaThomas Eiwegger
Mar 6, 2018·Immune Network·Hyun Jung ParkSeokmann Hong
Aug 2, 2017·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D Lozano-OjalvoR López-Fandiño
Jan 18, 2020·Current Allergy and Asthma Reports·Andrew LongR Sharon Chinthrajah
Dec 29, 2020·Frontiers in Immunology·Ayesha AliGerard E Kaiko
Aug 8, 2020·Pharmacology & Therapeutics·Partho Protim AdhikarySarah Hedtrich

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Methods Mentioned

BETA
FCS
PCR
ELISA

Software Mentioned

KS EliSpot

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