Jul 16, 2017

Food allergy phenotypes: The key to personalized therapy

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
A DeschildreJocelyne Just

Abstract

Food allergies (FAs) are of increasing public health concern and are characterized by a large spectrum of diseases. Their diversity is well known for immunologic pathways (IgE, non-IgE-mediated FAs) and natural history. Many other factors and patient characteristics are involved including type of food, exposure route, allergic comorbidities, gender, racial and ethnic backgrounds, cofactors and health conditions. Food allergen components and sensitization profiles are also involved in FA phenotypes. A new approach to chronic disorders based on the identification of phenotypes through extensive knowledge of all the complex components is also applicable to FAs and could lead towards integrative care management. Diagnostic biomarkers for FAs are emerging which also contribute to better care modalities. The aim of this article was to highlight current knowledge regarding the phenotypic diversity of FA. This review will focus on IgE-mediated FAs and how identifying phenotypes may help to better understand the pathophysiological complexity, improve diagnosis and lead to personalized treatment strategies.

  • References69
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References

  • References69
  • Citations11

Citations

Mentioned in this Paper

Biological Markers
Food Allergy Allergen
Fanconi Anemia
Biochemical Pathway
Treatment Protocols
Variolation
Food allergen
Immediate Hypersensitivity
Complex (molecular entity)
Food

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