Food allergy: what are the issues?

Toxicology Letters
I Kimber, R J Dearman

Abstract

With a growing interest in the development of genetically modified crop plants there is a need for appropriate approaches to safety assessment. Among the issues that have to be addressed is consideration of whether the products of novel genes have the potential to cause allergic sensitization. Resulting from a collaboration between the International Food Biotechnology Council and the International Life Sciences Institute recommendations have been made for a step-wise approach to the assessment of allergenic potential based upon considerations of serological identity, and sequence or structural homology, with known allergens and examination of the stability of the test protein in a simulated gastric fluid. In parallel there has been interest in the development of animal models, which would permit a more direct evaluation of potential allergenic activity. Progress in these areas is reviewed briefly in the context of what is known of food allergy and some of the important issues, which must be addressed in designing safety assessment strategies identified.

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Citations

Sep 10, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R J DearmanI Kimber
Apr 5, 2003·Toxicology Letters·Ian KimberRebecca J Dearman
Oct 24, 2002·Journal of Pediatric Gastroenterology and Nutrition·Hilary A Perr
Jan 1, 2011·Clinical and Translational Allergy·Apostolos BossiosPhotini Papageorgiou
Jul 5, 2003·Biological & Pharmaceutical Bulletin·Kayoko TakagiJun-ichi Sawada
Jun 27, 2003·Environmental Health Perspectives·Ian KimberRicki M Helm
Aug 25, 2011·Allergologia et immunopathologia·G PaşaoğluZ Misirligil
Nov 18, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R J DearmanI Kimber
Apr 8, 2015·Critical Reviews in Food Science and Nutrition·M PradoJ Barros-Velázquez
Feb 8, 2003·Environmental Health Perspectives·Ian KimberRebecca J Dearman
Dec 12, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·X LiuJ X Liu
Jan 7, 2004·Journal of Agricultural and Food Chemistry·Ovidiu IvanciucCatherine H Schein

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