Mar 28, 2012

Food and drug cues activate similar brain regions: a meta-analysis of functional MRI studies

Physiology & Behavior
D W TangAlain Dagher

Abstract

In healthy individuals, food cues can trigger hunger and feeding behavior. Likewise, smoking cues can trigger craving and relapse in smokers. Brain imaging studies report that structures involved in appetitive behaviors and reward, notably the insula, striatum, amygdala and orbital frontal cortex, tend to be activated by both visual food and smoking cues. Here, by carrying out a meta-analysis of human neuro-imaging studies, we investigate the neural network activated by: 1) food versus neutral cues (14 studies, 142 foci) 2) smoking versus neutral cues (15 studies, 176 foci) 3) smoking versus neutral cues when correlated with craving scores (7 studies, 108 foci). PubMed was used to identify cue-reactivity imaging studies that compared brain response to visual food or smoking cues to neutral cues. Fourteen articles were identified for the food meta-analysis and fifteen articles were identified for the smoking meta-analysis. Six articles were identified for the smoking cue correlated with craving analysis. Meta-analyses were carried out using activation likelihood estimation. Food cues were associated with increased blood oxygen level dependent (BOLD) response in the left amygdala, bilateral insula, bilateral orbital frontal corte...Continue Reading

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  • Citations103

References

Mentioned in this Paper

Imaging Studies
Drug Response
Biological Neural Networks
Dioxygen
Meta-Analysis (Publications)
Cortex Bone Disorders
Adrenal Cortex Diseases
Mango allergenic extract
Neostriatum
Cues

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