Food and food supplements with hypocholesterolemic effects

Recent Patents on Food, Nutrition & Agriculture
Ruitang Deng

Abstract

Hypercholesterolemia is a predominant risk factor for atherosclerosis and associated coronary and cerebrovascular diseases. Control of cholesterol levels through therapeutic drugs, notably statins, have significantly reduced the risk for developing atherosclerosis and associated cardiovascular diseases. However, adverse effects associated with therapeutic drugs warrant to find other alternative approaches for managing hypercholesterolemia, especially for those with borderline cholesterol levels. Food supplements have increasingly become attractive alternatives to prevent or treat hypercholesterolemia and reduce the risk for cardiovascular diseases. This review summarized current patents on food supplements with claims of hypocholesterolemic effects. They can be mainly divided into four categories based on the active ingredients in the supplements: 1) plant sterols or stanols; 2) fiber or polysaccharides; 3) microorganism-derived; and 4) soy protein and phytoestrogens. The efficacy, mechanisms of action and potential side effects are reviewed for each of the four categories. The hypocholesterolemic effects of plant sterols, fiber, Monascus products and soy protein preparations have been consistently demonstrated in clinical trai...Continue Reading

Citations

Oct 10, 2013·Molecular Nutrition & Food Research·Camelia Sorina StancuAnca Volumnia Sima
Apr 23, 2014·Scientific Reports·Keiko TanakaShinjiro Imai
Oct 17, 2012·Nutrition Research Reviews·Janice I Harland
Apr 27, 2021·Oxidative Medicine and Cellular Longevity·Ying Nie, Feijun Luo

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