Food and Gastroesophageal Reflux Disease

Current Medicinal Chemistry
Teodora Surdea-BlagaDan L Dumitrascu

Abstract

Gastroesophageal reflux disease is a chronic condition with a high prevalence in western countries. Transient lower esophageal sphincter relaxation episodes and a decreased lower esophageal sphincter pressure are the main mechanisms involved. Currently used drugs are efficient on reflux symptoms, but only as long as they are administered, because they do not modify the reflux barrier. Certain nutrients or foods are generally considered to increase the frequency of gastroesophageal reflux symptoms, therefore physicians recommend changes in diet and some patients avoid bothering foods. This review summarizes current knowledge regarding food and gastroesophageal reflux. For example, fat intake increases the perception of reflux symptoms. Regular coffee and chocolate induce gastroesophageal reflux and increase the lower esophageal exposure to acid. Spicy foods might induce heartburn, but the exact mechanism is not known. Beer and wine induce gastroesophageal reflux, mainly in the first hour after intake. For other foods, like fried food or carbonated beverages data on gastroesophageal reflux is scarce. Similarly, there are few data about the type of diet and gastroesophageal reflux. Mediterranean diet and a very low carbohydrate di...Continue Reading

References

Apr 1, 1978·Gut·S E Kaufman, M D Kaye
Aug 1, 1975·The American Journal of Digestive Diseases·L E Wright, D O Castell
Nov 9, 1975·The New England Journal of Medicine·S Cohen, G H Booth
Oct 1, 1985·Gastroenterology·R H HollowayR W McCallum
Dec 16, 1982·The New England Journal of Medicine·W J DoddsM S Egide
Jun 1, 1994·Alimentary Pharmacology & Therapeutics·B WendlH Kaess
Jun 1, 1993·Gut·S ChariM V Singer
Jan 1, 1993·Digestive Diseases and Sciences·C PehlH Kaess
May 1, 1996·Digestive Diseases and Sciences·K IwakiriY Nakagawa
Jun 1, 1997·Alimentary Pharmacology & Therapeutics·C PehlH Kaess
Nov 15, 1997·Scandinavian Journal of Gastroenterology·T LindA Stubberöd
Jan 13, 2000·Alimentary Pharmacology & Therapeutics·S Rodriguez-StanleyP B Miner
Apr 14, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·T PicheJ P Galmiche
Aug 2, 2001·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M BouinP Ducrotté
Oct 16, 2001·Gut·J H MeyerE A Mayer
Mar 8, 2003·Alimentary Pharmacology & Therapeutics·S D MartinezR Fass
Jul 3, 2003·JAMA : the Journal of the American Medical Association·Magnus NilssonJesper Lagergren
May 27, 2004·World Journal of Gastroenterology : WJG·Jin-Hai WangMing Tong
Jun 17, 2004·JAMA : the Journal of the American Medical Association·Allison A HedleyKatherine M Flegal
Jan 19, 2005·The American Journal of Gastroenterology·Kenneth R DeVaultUNKNOWN American College of Gastroenterology
Apr 2, 2005·Alimentary Pharmacology & Therapeutics·I MohammedN J Trudgill
Aug 3, 2005·Annals of Internal Medicine·Howard HampelHashem B El-Serag
Jan 6, 2006·The American Journal of Gastroenterology·Yasuhiro FujiwaraTetsuo Arakawa
Feb 17, 2006·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·P ZentilinV Savarino
Apr 6, 2006·JAMA : the Journal of the American Medical Association·Cynthia L OgdenKatherine M Flegal
Jun 2, 2006·The New England Journal of Medicine·Brian C JacobsonCarlos A Camargo
Jul 28, 2006·Digestive Diseases and Sciences·Gregory L AustinNicholas J Shaheen
Aug 22, 2006·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·L GrossiL Marzio
Aug 25, 2006·The American Journal of Gastroenterology·Nimish VakilUNKNOWN Global Consensus Group
Sep 6, 2006·The American Journal of Gastroenterology·Douglas A Corley, Ai Kubo
Feb 27, 2007·The American Journal of Gastroenterology·John E PandolfinoPeter J Kahrilas
Mar 17, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Mark FoxTerry Wong

❮ Previous
Next ❯

Citations

Oct 2, 2019·Journal of Digestive Diseases·Ling ZhangDuo Wu Zou
Jul 23, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Yuan LiXia Ding
Jun 25, 2020·Digestive Diseases and Sciences·Cesare TosettiUNKNOWN Study Group for the Evaluation of GERD Triggering Foods
Aug 20, 2020·Journal of Science and Medicine in Sport·Caio E G ReisTeresa H M da Costa
Feb 13, 2021·Nutrients·Kelly Anne ErdmanJill A Parnell
Mar 20, 2021·The Nurse Practitioner·Julia Rogers, Taryn Eastland
Apr 23, 2021·Therapeutics and Clinical Risk Management·Mei ZhangFeng-Bin Liu
Sep 30, 2021·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Youli ChenTao Bai
Oct 12, 2021·Annual Review of Nutrition·Krista A VaradyKelsey Gabel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.