PMID: 7514281Jan 1, 1994Paper

Food deprivation increases brain nitric oxide synthase and depresses brain serotonin levels in rats

Neuropharmacology
F SquadritoA P Caputi

Abstract

We studied nitric oxide (NO) synthase activity and serotonin content in the diencephalon of 24 hr food deprived rats. NO synthase activity was significantly increased whereas serotonin levels together with those of tryptophan and 5-hydroxyindoleacetic acid (5-HIAA) were reduced in food deprived rats when compared to control rats. NG-Nitro-L-arginine (L-NO Arg), an inhibitor of NO synthase, was used as a tool to study the role of NO in food deprivation. Twenty-four hr food deprived male Sprague-Dawley rats were intraperitoneally (i.p.) administered L-NO Arg (12.5, 25 and 50 mg/kg) before food presentation. Control rats received a NaCl (0.9%) solution. Food consumption was monitored 1 and 2 hr after food presentation. L-NO Arg administration produced a dose-dependent reduction in food intake. Pretreatment with metergoline (2 mg/kg) but not with ritanserin (1 mg/kg) antagonized the anorectic effect of L-NO Arg. Moreover, in the diencephalon L-NO Arg significantly reduced NO synthase activity whereas it increased serotonin levels. Our data indicate that NO might have a physiological role in the regulation of food intake and suggest that brain NO may modulate the central serotoninergic system.

References

Aug 1, 1992·Neuropharmacology·G CalapaiA P Caputi
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D S Bredt, S H Snyder
May 15, 1991·Biochemical and Biophysical Research Communications·M A DwyerS H Snyder
Jan 1, 1991·Life Sciences·J E Morley, J F Flood
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R G KnowlesS Moncada
Nov 30, 1989·Biochemical and Biophysical Research Communications·H H SchmidtE Böhme
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L J IgnarroG Chaudhuri
Oct 1, 1988·Hypertension·S MoncadaE A Higgs
Sep 13, 1988·European Journal of Pharmacology·H H SchmidtE Böhme

❮ Previous
Next ❯

Citations

Aug 10, 2010·Journal of Physiology and Biochemistry·Bessem MornaguiNajoua Gharbi
Sep 5, 1995·European Journal of Pharmacology·S C Hui, T Y Chan
Sep 5, 1996·European Journal of Pharmacology·J E MorleyJ F Flood
May 1, 1996·Progress in Neuro-psychopharmacology & Biological Psychiatry·B M Rabin
May 10, 1996·Neuroscience Letters·J E Morley, M B Mattammal
Dec 1, 1996·Neuroscience·C GuazaG Giménez-Gallego
Dec 1, 1994·Current Opinion in Neurobiology·I Kupfermann
Apr 20, 2005·Brain Research. Molecular Brain Research·Wenhua WangKent Lundholm
Nov 1, 1996·Pharmacology, Biochemistry, and Behavior·D A Czech
Jan 1, 1997·Pharmacology, Biochemistry, and Behavior·J E MorleyJ F Flood
Jun 4, 1998·Pharmacology, Biochemistry, and Behavior·D A CzechK T Le Sueur
Dec 14, 1999·Journal of Neuroscience Methods·L A BrownT A Lovick
Feb 5, 2002·Archives of Medical Research·M Gerardo Barragán-MejíaDaniel Santamaría-Del Angel
Jan 1, 1997·Brain Research Bulletin·S Ceccatelli
Aug 12, 1999·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·R VozzoJ E Morley
Aug 1, 1996·European Journal of Clinical Investigation·W M SunM Horowitz
Oct 8, 1999·The Journal of Clinical Investigation·G CalapaiA P Caputi
Jan 10, 2003·Biological & Pharmaceutical Bulletin·Yumi SugimotoJun Yamada
Jul 18, 2002·Japanese Journal of Pharmacology·Shizuko TsuchiyaKazuo Watanabe
Jun 7, 2014·Poultry Science·C WangM Xie
Nov 11, 2008·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·David Calderón GuzmánHugo Juárez Olguín
Jul 17, 2007·Physiology & Behavior·S J Yang, D M Denbow

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.