PMID: 9181629May 1, 1997Paper

Food-deprivation increases cocaine-induced conditioned place preference and locomotor activity in rats

Psychopharmacology
S M BellR A Meisch

Abstract

Food-deprivation increases the reinforcing efficacy of cocaine and other drugs within self-administration experiments. In this study, the effects of food-deprivation on cocaine-induced conditioned place preference were investigated. Male Sprague-Dawley rats were assigned to one of two feeding conditions: satiated (with ad libitum food) or deprived (maintained at 80% of free-feeding body weights). During conditioning trials, on alternate days, rats received IP injections of cocaine (0.0, 2.5, 5.0, or 10.0 mg/kg; n = 12 per dose group) and were confined for 30 min in one of two distinct environments. On intervening days, the same rats were injected with saline and confined for 30 min in the opposite environment. After four cocaine and four saline trails, a 15-min choice test (with no injections) was given. During this time, the rats were able to move freely through a passageway between both environments. Relative to the food-satiated rats, the food-deprived rats showed a greater conditioned preference for the cocaine-paired environment during the choice test, greater cocaine-induced locomotor activity during conditioning trials, and a greater degree of sensitization to the activating effects of cocaine across conditioning trials....Continue Reading

Citations

Jun 30, 2005·Psychopharmacology·Benoît ForgetMarie-Hélène Thiébot
Jul 14, 2011·Psychopharmacology·Amanda L SharpeMichael J Beckstead
Jun 12, 2001·Physiology & Behavior·D P FiglewiczP J Havel
Jun 19, 1998·Pharmacology, Biochemistry, and Behavior·S M BellS C Woods
Jun 4, 2004·Behavioral Neuroscience·Dianne P FiglewiczStephen C Benoit
Sep 22, 2005·Experimental and Clinical Psychopharmacology·Frances K McSweeneyBenjamin P Kowal
Jun 21, 2014·Psychopharmacology·Vassilis N Panagopoulos, Elizabeth Ralevski
Sep 4, 2015·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Petra SuchankovaElisabet Jerlhag
May 4, 2011·Journal of Neuroscience Methods·Sandra L Rokosik, T Celeste Napier
Aug 11, 2010·Behavioural Brain Research·Jennifer L WalkerDavid M Rector
Jan 1, 2008·Drug Discovery Today. Disease Models·Jasmine J Yap, Klaus A Miczek
Dec 9, 2008·Drug and Alcohol Dependence·Paul J WellmanBruce E Blough
Jul 26, 2008·European Journal of Pharmacology·Rajkumar J SevakCharles P France
May 24, 2008·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Manoranjan S D'Souza, Christine L Duvauchelle
Jul 22, 2008·Appetite·Dianne Figlewicz Lattemann
Dec 25, 2007·European Journal of Pharmacology·Rajkumar J SevakCharles P France
Dec 25, 2007·Physiology & Behavior·Jonathan A ZombeckJustin S Rhodes

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