Food for thought: the role of dietary flavonoids in enhancing human memory, learning and neuro-cognitive performance.

The Proceedings of the Nutrition Society
Jeremy P E Spencer

Abstract

Emerging evidence suggests that dietary-derived flavonoids have the potential to improve human memory and neuro-cognitive performance via their ability to protect vulnerable neurons, enhance existing neuronal function and stimulate neuronal regeneration. Long-term potentiation (LTP) is widely considered to be one of the major mechanisms underlying memory acquisition, consolidation and storage in the brain and is known to be controlled at the molecular level by the activation of a number of neuronal signalling pathways. These pathways include the phosphatidylinositol-3 kinase/protein kinase B/Akt (Akt), protein kinase C, protein kinase A, Ca-calmodulin kinase and mitogen-activated protein kinase pathways. Growing evidence suggests that flavonoids exert effects on LTP, and consequently memory and cognitive performance, through their interactions with these signalling pathways. Of particular interest is the ability of flavonoids to activate the extracellular signal-regulated kinase and the Akt signalling pathways leading to the activation of the cAMP-response element-binding protein, a transcription factor responsible for increasing the expression of a number of neurotrophins important in LTP and long-term memory. One such neurotr...Continue Reading

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Citations

Oct 22, 2008·Genes & Nutrition·David VauzourJeremy P E Spencer
Feb 19, 2013·Brain Research Bulletin·Yi LiuXiaoxing Yin
Oct 20, 2010·The British Journal of Nutrition·Jeremy P E Spencer
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