Food mineral composition and acid-base balance in preterm infants

European Journal of Nutrition
H KalhoffHeidrun Kiwull-Schöne

Abstract

Due to a transient age-related low renal capacity for net acid excretion, preterm infants fed formula are at a considerable risk of spontaneously developing incipient late metabolic acidosis, clinically characterized by e.g., disturbed bone mineralization and impaired growth. From acid-base data in blood and urine under different diets of modified human milk or preterm formulas is attempted to explore the impact of food mineral (and protein) composition on renal regulation and systemic acid-base balance in preterm infants. Data were collected from 48 infants fed their own mother's milk (28 native human milk, 20 enriched with fortifier) and 34 patients on formula (23 on a standard batch, 11 on a modified batch with reduced acid load). Intake of food was measured and acid-base data were determined in blood and timed-urine (8-12 h) samples. Differences in mineral composition of the diets led to considerable differences of daily "alkali-intake", without significant effects on non-respiratory (base excess, BE) and respiratory (PCO(2)) acid-base data in the blood. In contrast, a highly significant proportionality between individual dietary alkali intake and daily renal base (Na(+) + K(+)-Cl(-)) excretion was observed (y = 0.32x-0.70,...Continue Reading

References

Mar 1, 1974·Acta paediatrica Scandinavica·V Andersen, E Andersen
Mar 1, 1972·Clinica Chimica Acta; International Journal of Clinical Chemistry·H BartelsC Heierli
Jul 1, 1995·Journal of the American Dietetic Association·T Remer, F Manz
Jun 1, 1994·The American Journal of Clinical Nutrition·T Remer, F Manz
Jan 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G H KimJ S Lee
Jan 1, 1995·Acta Anaesthesiologica Scandinavica. Supplementum·O Siggaard-Andersen, N Fogh-Andersen
Aug 1, 1996·The American Journal of Clinical Nutrition·A LucasN J Bishop
Aug 1, 1996·The American Journal of Clinical Nutrition·R J Schanler
Feb 1, 1997·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R J Alpern, Khashayar Sakhaee
Apr 1, 1997·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·F ManzT Remer
Jul 31, 1998·Journal of Dairy Science·D B Vagnoni, G R Oetzel
May 5, 2000·The Cochrane Database of Systematic Reviews·C A Kuschel, J E Harding
Mar 10, 2001·Pediatric Clinics of North America·R J Schanler
Dec 12, 2001·Journal of Pediatric Gastroenterology and Nutrition·H KalhoffF Manz
Feb 15, 2002·European Journal of Nutrition·T Remer
Feb 15, 2002·European Journal of Nutrition·H Kalhoff, F Manz
Jun 18, 2004·Seminars in Perinatology·Raymond Quigley, Michel Baum
Feb 8, 2005·European Journal of Nutrition·Heidrun Kiwull-SchönePeter Kiwull
May 2, 2006·European Journal of Nutrition·Christian DemignéPierre Meneton

Citations

Sep 2, 2014·BMC Pediatrics·Dominica A Gidrewicz, Tanis R Fenton
Aug 12, 2014·European Journal of Pediatrics·Sergio Verd, María-José García
Jul 31, 2016·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Gemma GinovartSergio Verd
Jan 23, 2016·The American Journal of Clinical Nutrition·Daniel J RaitenPre-B Consultative Working Groups
Dec 30, 2017·Journal of Neonatal-perinatal Medicine·Shabnam LainwalaElizabeth A Brownell
Dec 17, 2011·Journal of Pediatric Gastroenterology and Nutrition·Elsa Kermorvant-DucheminAlexandre Lapillonne
Aug 26, 2020·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Erika G CordovaMandy Brown Belfort
Jul 22, 2017·Nutrition & Dietetics : the Journal of the Dietitians Association of Australia·Benjamin H ParmenterLynda A Frassetto
Nov 21, 2019·Developmental Medicine and Child Neurology·Björn BjurulfPetter Strømme
Jan 22, 2008·The Journal of Nutrition·Heidrun Kiwull-SchöneH Kalhoff

Related Concepts

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