PMID: 15374413Jan 1, 1992Paper

Food restriction in female Wistar rats: V. Lipid peroxidation and antioxidant enzymes in the liver

Archives of Gerontology and Geriatrics
C PieriG Lupidi

Abstract

The activities of antioxidant enzymes as well as the levels of basal and enzyme induced peroxidation have been investigated in liver of female Wistar undernourished rats. Food restriction was applied starting from the age of 3.5 months by feeding the animals on every-other-day schedule (EOD). Diet restriction prevented the age-dependent increase of basal and enzyme induced lipid peroxidation in both mitochondrial and microsomal liver membrane preparations. The activities of antioxidant enzyme, i.e. superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) of liver decreased during aging in ad libitum fed rats. In the diet conditioned animals, a small increase of SOD and a complete recovery of CAT activities were observed. Present data support that food restriction improved the protection against peroxidation, and this may be in close relationship with the life prolonging effect of such a treatment.

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Citations

Dec 1, 1991·Aging : Clinical and Experimental Research·C PieriR Recchioni
Nov 18, 2004·Biogerontology·Fausto MoroniCarlo Bertoni-Freddari
Mar 1, 1995·Archives of Gerontology and Geriatrics·C PieriR Recchioni
Nov 1, 1992·Comparative Biochemistry and Physiology. Comparative Physiology·C PieriF Marcheselli
Jun 5, 2002·Mechanisms of Ageing and Development·ZhongMao GuoRobert Reddick
Oct 26, 2014·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Hari N BhilwadeR C Chaubey
Jun 10, 2014·Dose-response : a Publication of International Hormesis Society·Michael Ristow, Kathrin Schmeisser
May 31, 2011·Free Radical Biology & Medicine·Michael Ristow, Sebastian Schmeisser
Nov 19, 2014·Proceedings of the National Academy of Sciences of the United States of America·Mark P MattsonSatchidananda Panda
Nov 16, 2004·Mechanisms of Ageing and Development·Alex BokovArlan Richardson

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