Food restriction research: Its significance for human aging

American Journal of Human Biology : the Official Journal of the Human Biology Council
E J Masoro

Abstract

The total lack of knowledge concerning the nature of the primary aging processes coupled to the lack of biomarkers of aging has made it difficult to devise fruitful approaches for the study of aging. Indeed, the only index of aging about which there is general agreement is the life span of the species (i.e., the maximum age attained by members of the species). Only one manipulation has been found which extends the life span of a mammalian species and that is food restriction in rodents. In addition to increasing life span, food restriction also retards almost all age-associated physiological changes and diseases processes. It is concluded that food restriction has these diverse actions because it retards the primary aging processes. Recent research has been focused on the mechanisms by which food restriction influences the primary aging processes because it is believed that such knowledge will provide insight on the basis nature of aging. Available evidence pints to the neural an endocrine system as couplers of food restriction to the aging processes. Of particular current interest are the effects of food restriction on protein turnover and free radical metabolism. The importance of food restriction to human aging relates to th...Continue Reading

References

Jan 1, 1989·Journal of Gerontology·E J MasoroC A McMahan
May 2, 1985·The New England Journal of Medicine·E L Schneider, J D Reed
Aug 1, 1986·Endocrine Reviews·R M SapolskyB S McEwen
Jan 1, 1986·Journal of Chronic Diseases·J A Brody, E L Schneider
Jun 30, 1987·Biochemical and Biophysical Research Communications·S Laganiere, B P Yu
Sep 1, 1985·Journal of the American Geriatrics Society·A Cerami
Jan 1, 1985·Basic Life Sciences·B J Merry, A M Holehan
May 1, 1985·The American Journal of Physiology·C SumnersM K Raizada
Nov 1, 1985·Journal of Gerontology·H MaedaB P Yu
Jan 1, 1980·Endocrine Reviews·J W Rowe, B R Troen
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·D E HarrisonC M Astle
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·E J MasoroH A Bertrand

❮ Previous
Next ❯

Citations

Nov 18, 2000·The American Psychologist·J P PinelD R Lehman
Dec 8, 1996·Assistive Technology : the Official Journal of RESNA·M R TomitaL L Burns
Apr 8, 2015·Journal of Gerontological Nursing·Neda AmirkhosraviMasoumeh Hosseinian
Jan 1, 1996·International Journal of Health Services : Planning, Administration, Evaluation·D L Skillen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Aging-Associated Metabolic Disorders

Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

© 2022 Meta ULC. All rights reserved