Food-specific IgG4-guided exclusion diets improve symptoms in Crohn's disease: a pilot study

Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland
N Rajendran, D Kumar

Abstract

Exclusion diets have been shown to prolong remission in Crohn's disease (CD). We assessed IgG4-targeted exclusion diets in patients with CD. Forty patients with symptomatic CD were recruited. Their sera were tested for IgG4 antibodies to 14 specific food antigens and each subject's four most reactive foods were excluded for 4 weeks. Disease activity was assessed using a modified CD activity index (mCDAI). Questionnaire and inflammatory markers were measured before and on completion of the exclusion diet. Eleven patients did not complete the study, leaving 29 for analysis. Of these, 26 (90%) reported symptomatic improvement with a reduction in mCDAI from a mean of 171-97.5 (P = 0.0001). The ESR fell from 23 to 17 mm/h (P = 0.021) and the IgG4 titres for the excluded foods fell from a mean of 3015-2306 mcgA/l (P = 0.003). IgG4-guided exclusion diets resulted in significant symptomatic improvement with an objective fall in an inflammatory marker. This approach may be useful in clinical practice.

References

Jun 1, 1993·Gut·M PearsonI Bjarnason
Feb 1, 1997·Alimentary Pharmacology & Therapeutics·T S KingJ O Hunter
Jul 4, 2003·European Journal of Gastroenterology & Hepatology·Kevin D Cashman, F Shanahan
Aug 20, 2005·Scandinavian Journal of Gastroenterology·Sameer ZarDevinder Kumar
Oct 1, 1993·Archives of Disease in Childhood·D P Davies

❮ Previous
Next ❯

Citations

May 11, 2012·Current Opinion in Gastroenterology·Lindsey G AlbenbergGary D Wu
Aug 8, 2014·Journal of Gastroenterology·Takaaki KawaguchiMasakazu Takazoe
Oct 11, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Jason K HouJames Lewis
Aug 28, 2012·Digestive Diseases and Sciences·Aaron B CohenJames D Lewis
Jan 27, 2016·Digestive Diseases and Sciences·Viran GunasekeeraDevinder Kumar
Jan 9, 2015·Critical Reviews in Food Science and Nutrition·Ashley CharleboisBrian Bressler
Apr 23, 2016·International Journal of Molecular Sciences·Mario MatijašićDonatella Verbanac
Jul 28, 2016·Scandinavian Journal of Gastroenterology·Anke JansenGernot Sellge
Jan 13, 2017·Inflammatory Bowel Diseases·James D LewisWalter Reinisch
Nov 18, 2018·Journal of Digestive Diseases·Yi Quan ZhouYan Ping Wan
Feb 9, 2019·The Cochrane Database of Systematic Reviews·Berkeley N LimketkaiGerard E Mullin
May 11, 2019·Nutrients·Fernando RizzelloPaolo Gionchetti
Oct 3, 2020·Nutrients·Hannah MortonJane Coad
Apr 12, 2017·Current Gastroenterology Reports·Kristin E BurkeAshwin N Ananthakrishnan
May 30, 2020·Yonsei Medical Journal·Sung Ryeol KimJung Won Park
Dec 6, 2019·Therapeutic Advances in Gastroenterology·Bénédicte Pigneur, Frank M Ruemmele
Dec 10, 2019·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Alexa N SassonMaitreyi Raman
Apr 4, 2021·Nutrients·Judith WellensJoão Sabino
Mar 16, 2019·Gastroenterology·Lindsey AlbenbergJames D Lewis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.