Food supplementation with an olive (Olea europaea L.) leaf extract reduces blood pressure in borderline hypertensive monozygotic twins

Phytotherapy Research : PTR
Tania Perrinjaquet-MoccettiCem Aydogan

Abstract

Hypertension is a harmful disease factor that develops unnoticed over time. The treatment of hypertension is aimed at an early diagnosis followed by adequate lifestyle changes rather than pharmacological treatment. The olive leaf extract EFLA943, having antihypertensive actions in rats, was tested as a food supplement in an open study including 40 borderline hypertensive monozygotic twins. Twins of each pair were assigned to different groups receiving 500 or 1000 mg/day EFLA943 for 8 weeks, or advice on a favourable lifestyle. Body weight, heart rate, blood pressure, glucose and lipids were measured fortnightly. Blood pressure changed significantly within pairs, depending on the dose, with mean systolic differences of < or =6 mmHg (500 mg vs control) and < or =13 mmHg (1000 vs 500 mg), and diastolic differences of < or =5 mmHg. After 8 weeks, mean blood pressure remained unchanged from baseline in controls (systolic/diastolic: 133 +/- 5/77 +/- 6 vs 135 +/- 11/80 +/- 7 mmHg) and the low-dose group (136 +/- 7/77 +/- 7 vs 133 +/- 10/76 +/- 7), but had significantly decreased for the high dose group (137 +/- 10/80 +/- 10 vs 126 +/- 9/76 +/- 6). Cholesterol levels decreased for all treatments with significant dose-dependent within-p...Continue Reading

Associated Clinical Trials

References

Oct 1, 1991·Planta medica·A ZarzueloM P Utrilla
Jun 24, 1998·Biochemical and Biophysical Research Communications·F VisioliC Galli
Nov 5, 2003·Journal of Hypertension·Judith A Whitworth, UNKNOWN World Health Organization, International Society of Hypertension Writing Group
Sep 24, 2004·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Javier S PeronaValentina Ruiz-Gutiérrez
Sep 28, 2004·The American Journal of Clinical Nutrition·Theodora PsaltopoulouAntonia Trichopoulou
Feb 11, 2005·Clinical and Experimental Hypertension : CHE·Jacques de ChamplainLingyun Wu
Feb 23, 2005·Hypertension·David M Pollock
Mar 2, 2005·Lipids·Alvaro Alonso, Miguel Angel Martínez-González
Jul 20, 2005·Current Vascular Pharmacology·Nelson Escobales, Maria J Crespo
Sep 1, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Peter BolliUNKNOWN Canadian Hypertension Education Program
Jan 26, 2006·Hypertension·Lawrence J AppelUNKNOWN American Heart Association
Mar 1, 1996·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·K HansenU W Smitt

❮ Previous
Next ❯

Citations

Dec 23, 2009·The British Journal of Nutrition·Tamara CvjetićaninStanislava Stosić-Grujicić
Oct 26, 2012·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Andreas Busjahn
Sep 13, 2015·Annals of Medicine·Cesare R SirtoriArrigo F G Cicero
Nov 3, 2010·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Endang SusalitMarian Verbruggen
Oct 15, 2013·The Journal of Clinical Hypertension·Mark Houston
Oct 26, 2012·TheScientificWorldJournal·Mian-Ying WangBrett J West
Mar 20, 2015·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Arrigo F G Cicero, Alessandro Colletti
Mar 25, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Muhammad Ali HashmiShagufta Perveen
Jul 17, 2015·Oxidative Medicine and Cellular Longevity·Matteo MicucciSilvana Hrelia
Jul 1, 2010·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Syed Haris Omar
Jul 8, 2016·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Nataša ZorićIvan Kosalec
May 26, 2017·Food & Function·Arrigo F G CiceroAlessandro Colletti
Jan 8, 2017·Redox Biology·Eduardo Lopez-Huertas, Juristo Fonolla
Jul 1, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bandhita SaibandithDaniel M Commane
Dec 15, 2015·International Journal of Toxicology·Amy E ClewellIlona Pasics Szakonyiné
Jul 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lorenzo CecchiMaria Camilla Bergonzi
Nov 1, 2016·Current Cardiology Reports·Jeffrey M Turner, Erica S Spatz
Aug 12, 2017·Journal of the Science of Food and Agriculture·Selin Şahin, Mehmet Bilgin
Dec 5, 2017·Oxidative Medicine and Cellular Longevity·Rehab F Abdel-RahmanSalah M Hassan
Oct 1, 2020·Food Science & Nutrition·Arshad MehmoodChengtao Wang
Jun 24, 2021·Natural Product Research·Alessio AlesciSimona Pergolizzi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.