PMID: 9557639Apr 29, 1998Paper

Foot-and-mouth disease virus virulent for cattle utilizes the integrin alpha(v)beta3 as its receptor

Journal of Virology
S NeffB Baxt

Abstract

Adsorption and plaque formation of foot-and-mouth disease virus (FMDV) serotype A12 are inhibited by antibodies to the integrin alpha(v)beta3 (A. Berinstein et al., J. Virol. 69:2664-2666, 1995). A human cell line, K562, which does not normally express alpha(v)beta3 cannot replicate this serotype unless cells are transfected with cDNAs encoding this integrin (K562-alpha(v)beta3 cells). In contrast, we found that a tissue culture-propagated FMDV, type O1BFS, was able to replicate in nontransfected K562 cells, and replication was not inhibited by antibodies to the endogenously expressed integrin alpha5beta1. A recent report indicating that cell surface heparan sulfate (HS) was required for efficient infection of type O1 (T. Jackson et al., J. Virol. 70:5282-5287, 1996) led us to examine the role of HS and alpha(v)beta3 in FMDV infection. We transfected normal CHO cells, which express HS but not alpha(v)beta3, and two HS-deficient CHO cell lines with cDNAs encoding human alpha(v)beta3, producing a panel of cells that expressed one or both receptors. In these cells, type A12 replication was dependent on expression of alpha(v)beta3, whereas type O1BFS replicated to high titer in normal CHO cells but could not replicate in HS-deficie...Continue Reading

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Citations

Sep 18, 2001·Journal of Virology·Y BoonyakiatG Stanway
Jan 5, 2002·Journal of Virology·Terry JacksonAndrew M Q King
May 10, 2013·The Journal of General Virology·Katja SchmidtMartin H Groschup
Jun 29, 2000·Annual Review of Biochemistry·M BernfieldM Zako
Aug 15, 2003·The Journal of General Virology·Heli HarvalaTimo Hyypiä
Feb 8, 2005·The Journal of Biological Chemistry·Boyd Butler, Scott D Blystone
Dec 18, 2008·The Journal of General Virology·Outi HeikkiläTimo Hyypiä
Nov 20, 2019·Viruses·Adithya SridharKatja C Wolthers
Apr 20, 2001·Journal of Virology·I G GoodfellowD J Evans
Jun 14, 2000·Journal of Virology·K TriantafilouN Fernandez
Feb 26, 2003·Journal of Medical Virology·Anja PaananenMerja Roivainen

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