Foot-shock stress-induced regional iron accumulation and altered iron homeostatic mechanisms in rat brain

Biological Trace Element Research
Long MaMin Li

Abstract

Like in other organs, iron in the brain plays an important role in various biological processes. Previous studies have shown that systemic iron homeostasis in mammalians was changed under specific stress conditions. The present study aimed to investigate effects of stress on brain iron homeostasis in rats using a foot-shock stress model. Young adult male Sprague-Dawley rats were randomly assigned to foot-shock stress group subjected to 30 min of cutaneous foot-shock (0.80 mA, 1 pulse/s, 300 ms duration) daily for 1 week or control group left undisturbed. Then, the rats were sacrificed and iron concentration in serum, liver, and some brain regions were measured using atomic absorption spectrophotometry. Expression of ferritin, Transferrin receptor (TfR), divalent metal transporter 1 (DMT1, with or without iron-responsive element), lactoferrin (Lf), and iron regulatory protein 1 (IRP1) in rat hippocampus were determined using western blot analysis. The results showed that stress induced decreased serum iron concentration, increased liver iron content, and elevated iron contents in specific brain regions including hippocampus, striatum, and frontal cortex. In the hippocampus, stress caused decreased expression of ferritin, increas...Continue Reading

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Citations

Dec 4, 2009·Biological Trace Element Research·Lei WangLi Lv
Mar 11, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·George BartzokisJames R Connor
Nov 5, 2013·Nitric Oxide : Biology and Chemistry·Qian Chen, De-Sheng Xiao
May 27, 2015·American Journal of Alzheimer's Disease and Other Dementias·Farzana PervinCarol F Lippa

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