Footrot vaccines and vaccination

Vaccine
Om DhungyelRichard Whittington

Abstract

Research on footrot in small ruminants, which is caused by Dichelobacter nodosus, has led to development of vaccines and their application for control, treatment and eradication of the disease in sheep. Footrot vaccines have evolved over decades to contain monovalent whole cell, multivalent recombinant fimbrial, and finally mono or bivalent recombinant fimbrial antigens. Initially whole cell vaccines made against the few known serogroups of D. nodosus were found to be inefficient in control of the disease in the field, which was attributed to the presence of other unidentified serogroups and also the use of inefficient adjuvants. Fimbriae or pili, which are the basis for antigenic variation, were found to be the major protective and also curative antigens but they are not cross protective between the different serogroups. Multivalent vaccines incorporating all the known serogroups have been proven to be of limited efficacy due to the phenomenon of antigenic competition. Recent studies in Nepal, Bhutan and Australia have shown that outbreak-specific vaccination which involves targeting identified serogroups with mono- or bivalent recombinant fimbrial vaccines, can be very effective in sheep and goats. Where multiple serogroups a...Continue Reading

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Citations

Jul 30, 2015·Veterinary Microbiology·D LacastaG C Fthenakis
Sep 1, 2015·Frontiers in Microbiology·Deborah R LeitnerStefan Schild
Dec 3, 2014·Vaccine·Vidya BhardwajRichard Whittington
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Related Concepts

Immunologic Adjuvants
Antigens, Bacterial
Bacterial Vaccines
Foot Rot
Bacterial Pilus
Vaccination
Semisynthetic Vaccines
Dichelobacter
Humoral Immune Response
Immunologic Adjuvants

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