"For COVID" or "With COVID": Classification of SARS-CoV-2 Hospitalizations in Children.

Hospital Pediatrics
Lauren E KushnerRoshni Mathew

Abstract

Pediatric hospitalization rates are used as a marker of coronavirus disease 2019 (COVID-19) disease severity in children but may be inflated by the detection of mild or asymptomatic infection via universal screening. We aimed to classify COVID-19 hospitalizations using an existing and novel approach and to assess the interrater reliability of both approaches. This retrospective cohort study characterized severity of illness and likelihood of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection as the cause of hospitalization in pediatric patients <18 years of age. Subjects had positive SARS-CoV-2 nasopharyngeal testing or were diagnosed with multisystem inflammatory syndrome in children and were hospitalized between May 10, 2020 (when universal screening of all admissions began) and February 10, 2021, at a university-based, quaternary care children's hospital in Northern California. Hospitalizations were categorized as either likely or unlikely to be caused by SARS-CoV-2 (novel approach), and disease severity was categorized according to previously published classification of disease severity. Of 117 hospitalizations, 46 (39.3%) were asymptomatic, 33 (28.2%) had mild to moderate disease, 9 (7.7%) had severe il...Continue Reading

References

Mar 18, 2020·Pediatrics·Yuanyuan DongShilu Tong
Apr 23, 2020·Journal of the Pediatric Infectious Diseases Society·Kathleen ChiotosMari M Nakamura
Jul 28, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Julie PolineNaïm Ouldali
Oct 2, 2020·MMWR. Morbidity and Mortality Weekly Report·Rebecca T LeebMatthew Lozier
Jan 12, 2021·JAMA Pediatrics·Zachary LevinPinar Karaca-Mandic
Jan 22, 2021·MMWR. Morbidity and Mortality Weekly Report·Eva LeidmanErin K Sauber-Schatz
Jan 23, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kimberly E HansonReem A Mustafa
Feb 14, 2021·The Lancet Child & Adolescent Health·Sarah BrookmanAtul Gupta

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Citations

Sep 17, 2021·European Journal of Clinical Investigation·John P A Ioannidis
Sep 29, 2021·The Journal of Clinical Endocrinology and Metabolism·Carla Demeterco-BerggrenDavid M Maahs
Jun 26, 2021·Hospital Pediatrics·Sandeep TripathiUNKNOWN Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Regist
Feb 27, 2022·European Journal of Pediatrics·Joanna MerckxJoan Robinson

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