For debate. Glucose variability and diabetes complication risk: we need to know the answer

Diabetic Medicine : a Journal of the British Diabetic Association
Eric S KilpatrickStephen L Atkin

Abstract

There is still a debate as to whether or not glucose variability contributes to diabetes complication risk. There is much in vitro laboratory evidence that glycaemic instability gives rise to increased production of reactive oxygen species and has a detrimental effect on endothelial dysfunction. While some in vivo studies have also shown similar findings in patients with or without diabetes, others have been unable to confirm any association. Furthermore, clinical studies which have sought to translate this possible risk into an increased likelihood of developing micro- or macrovascular complications have so far not demonstrated an effect. However, few of these trials were specifically designed to establish any influence of glucose fluctuations. This issue is now one of the largest remaining unanswered questions in diabetes. While this article focuses on the data which do not support a role for glucose variability in the development of complications, it also highlights the need for further studies to be performed which will definitively resolve the matter.

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Citations

Aug 21, 2012·Current Diabetes Reports·Masakazu HiroseKatie Weinger
Jun 28, 2011·Diabetes Technology & Therapeutics·F Javier Ampudia-BlascoJuan F Ascaso
Feb 1, 2011·Therapeutic Advances in Endocrinology and Metabolism·Luz Marina Prieto-Sanchez
Aug 13, 2013·Journal of Diabetes Research·Xingguang ZhangXiaofeng Lv
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Jun 2, 2017·Journal of Diabetes Science and Technology·Giada AcciaroliClaudio Cobelli
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Sep 2, 2011·Journal of Diabetes Science and Technology·Cynthia R MarlingFrank L Schwartz
Mar 20, 2013·Medicine and Science in Sports and Exercise·Jan-Willem Van DijkLuc J C Van Loon
Feb 19, 2013·Diabetic Medicine : a Journal of the British Diabetic Association·A J DawsonE S Kilpatrick
Sep 27, 2013·Diabetes, Obesity & Metabolism·F Cavalot
Jul 22, 2019·Diabetes Research and Clinical Practice·M Martínez-VenegasM G Arellano-Mendoza

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