For whom the endocannabinoid tolls: Modulation of innate immune function and implications for psychiatric disorders

Progress in Neuro-psychopharmacology & Biological Psychiatry
Rebecca J HenryMichelle Roche

Abstract

Toll-like receptors (TLRs) mediate the innate immune response to pathogens and are critical in the host defence, homeostasis and response to injury. However, uncontrolled and aberrant TLR activation can elicit potent effects on neurotransmission and neurodegenerative cascades and has been proposed to trigger the onset of certain neurodegenerative disorders and elicit detrimental effects on the progression and outcome of established disease. Over the past decade, there has been increasing evidence demonstrating that the endocannabinoid system can elicit potent modulatory effects on inflammatory processes, with clinical and preclinical evidence demonstrating beneficial effects on disease severity and symptoms in several inflammatory conditions. This review examines the evidence supporting a modulatory effect of endocannabinoids on TLR-mediated immune responses both peripherally and centrally, and the implications for psychiatric disorders such as depression and schizophrenia.

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Citations

Feb 10, 2016·Frontiers in Neurology·Sabrina F LisboaAlline C Campos
Sep 6, 2015·The International Journal of Neuropsychopharmacology·Marie FitzgibbonMichelle Roche
Apr 16, 2016·Neuropharmacology·John-Mark K Fitzpatrick, Eric J Downer
Jul 21, 2017·Journal of Neuroscience Research·Lisa E FlanneryMichelle Roche
Feb 28, 2018·Neuroimmunomodulation·Ruei-An ChenYi-Yung Hung
Dec 8, 2017·Frontiers in Immunology·Peter HolzerFlorian Reichmann
Dec 6, 2018·International Journal of Molecular Sciences·Ivan PrestaGiuseppe Donato
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Aug 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marykate KillileaAntony M Wheatley
Oct 8, 2020·International Journal of Molecular Sciences·Diogo M LourençoSara Xapelli

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