Force and stiffness of old dystrophic (mdx) mouse skeletal muscles

Muscle & Nerve
J BobetT Gordon

Abstract

It has recently been suggested, based on studies of tissue pathology, that the limb muscles of old mdx mice may be a good model for the muscular changes seen in human Duchenne muscular dystrophy. To test this hypothesis, we measured force and stiffness of soleus and extensor digitorum longus (EDL) muscles of old (20-21 months) mdx mice and age-matched controls. The mdx and control muscles generated similar twitch, tetanic, and eccentric forces. They were also equally stiff. The results show that the mechanics of aged mdx limb muscles differ greatly from Duchenne muscular dystrophy in humans, and disagree with the hypothesis.

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Mar 7, 2014·American Journal of Physiology. Cell Physiology·Lucas R Smith, Elisabeth R Barton
Feb 2, 2002·Nature Reviews. Genetics·James Gusella, Marcy MacDonald
Dec 26, 2008·American Journal of Physiology. Cell Physiology·Paul T MartinPaul M L Janssen
Mar 1, 2002·Muscle & Nerve·Hajime HaraKenneth H Fischbeck
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Apr 13, 2021·Journal of Neuromuscular Diseases·Sabrina Ben LarbiBénédicte Chazaud

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