Force transducer-based movement detection in fear conditioning in mice: a comparative analysis

Hippocampus
Thomas FitchRobert T Gerlai

Abstract

Fear conditioning (FC) allows the dissociation of hippocampal and nonhippocampal behavioral function in rodents, and has become a diagnostic tool in transgenic mouse research employed to investigate mutation-induced changes in brain function. Although the procedural details of the paradigm have been established, quantification of the behavioral output, freezing, remains problematic in mice. Observation-based techniques are time-consuming and may be subject to bias, while movement detection with photocells is imprecise. Here we describe an alternative method for movement detection, based on an electronic force transducer system that allows the quantification of acceleration forces generated by a moving subject. We compare the behavior of two inbred strains of mice (C57BL/6 and DBA/2) whose performance is known to differ in hippocampal tasks, including FC. The comparison is made using multiple techniques: the force transducer approach, and three observation-based methods, a computer-aided event-recording approach, a traditional time-sampling paper/pencil method, and a subjective impression-based scoring system. In addition, we investigate the correlation structures of behavioral elements quantified by event recording, using princ...Continue Reading

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Citations

Nov 14, 2002·Behavioural Brain Research·Robert GerlaiBruce D Gitter
Dec 7, 2007·Behavioural Brain Research·Natasha Speedie, Robert Gerlai
Aug 24, 2006·Neuropharmacology·Charles D KopecRoberto Malinow
Dec 26, 2006·Behavior Research Methods·Rachel Blaser, Robert Gerlai
Mar 17, 2017·Autism Research : Official Journal of the International Society for Autism Research·Manon GauducheauSusanna Pietropaolo
Apr 23, 2008·Current Protocols in Neuroscience·Jeanne M Wehner, Richard A Radcliffe
Aug 18, 2021·Neurobiology of Learning and Memory·L R SeemillerT J Gould

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