PMID: 3752234Sep 1, 1986Paper

Force-velocity curves for smooth muscle: analysis of internal factors reducing velocity

The American Journal of Physiology
C Y Seow, N L Stephens

Abstract

In tracheal smooth muscle, we obtained quantitatively different force-velocity (F-V) curves at early (2 s) and late (8 s) stages of an isometric tetanus whose contraction time was 12 s. These were essentially two samples from a continuum of F-V curves operating between 0 and 12 s. The cross-bridge cycling velocity at 8 s was slower and less sensitive to external load change compared with that at 2 s. This is possibly due to the presence of two types of cross bridges with different F-V characteristics; at 2 s most of the bridges resemble a cycling type, whereas at 8 s there is a population of what Dillon et al. have called slowly cycling or latch type interactions. Another possibility is that, due to some intrinsic factors, the whole population of cross bridges gradually change their F-V characteristics. Functions a(t) and b(t) were obtained by applying load clamps at 1-s intervals throughout a tetanus (a and b are asymptote values derived from the F-V hyperbolic curves): a increased with time, b remained constant. Analysis suggested that a/b was a valid index of internal factors that affect shortening velocity of unloaded muscle, and it is progressively increased in value during contraction.

References

Jun 1, 1971·The American Journal of Physiology·N L Stephens, U Kromer
Jun 1, 1969·Journal of Applied Physiology·N L StephensJ A Mehta

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Citations

Apr 19, 2002·Journal of Applied Physiology·Lu WangChun Y Seow
Dec 8, 2005·Canadian Journal of Physiology and Pharmacology·Farah AliChun Y Seow
Feb 1, 2019·Journal of Engineering and Science in Medical Diagnostics and Therapy·Chun Y Seow
Aug 24, 2000·Journal of Applied Physiology·C Y SeowL E Ford
Apr 1, 1992·Journal of Muscle Research and Cell Motility·R A Meiss
Sep 8, 2007·Canadian Journal of Physiology and Pharmacology·Steven S An, Jeffrey J Fredberg
Jun 4, 2011·Journal of Applied Physiology·Harley T SyyongChun Y Seow
Jan 6, 2007·Journal of Applied Physiology·Jason H T Bates, Anne-Marie Lauzon
Dec 13, 2012·Journal of Muscle Research and Cell Motility·Marion J SiegmanThomas M Butler
May 13, 2009·Pediatric Pulmonology·Rachel E LaudadioSteven P Driska
Jun 1, 2005·Journal of Cell Science·Ana M HerreraChun Y Seow
Sep 12, 1998·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·G C SieckK A Jones

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