Forced Abstinence From Alcohol Induces Sex-Specific Depression-Like Behavioral and Neural Adaptations in Somatostatin Neurons in Cortical and Amygdalar Regions

Frontiers in Behavioral Neuroscience
Nigel C DaoNicole A Crowley

Abstract

Forced abstinence (FA) from alcohol has been shown to produce a variety of anxiety- and depression-like symptoms in animal models. Somatostatin (SST) neurons, a subtype of GABAergic neurons found throughout the brain, are a novel neural target with potential treatment implications in affective disorders, yet their role in alcohol use disorders (AUD) remains to be explored. Here, we examined the neuroadaptations of SST neurons during forced abstinence from voluntary alcohol consumption. Following 6 weeks of two-bottle choice alcohol consumption and protracted forced abstinence, male and female C57BL/6J mice exhibited a heightened, but sex-specific, depressive-like behavioral profile in the sucrose preference test (SPT) and forced swim test (FST), without changes in anxiety-like behaviors in the elevated plus maze (EPM) and open field test (OFT). FST-induced cFos expressions in the prefrontal cortex (PFC) and ventral bed nucleus of the stria terminalis (vBNST) were altered in FA-exposed female mice only, suggesting a sex-specific effect of forced abstinence on the neural response to acute stress. SST immunoreactivity in these regions was unaffected by forced abstinence, while differences were seen in SST/cFos co-expression in the...Continue Reading

References

May 1, 1977·Journal of Studies on Alcohol·H I Hershon
Jun 1, 1991·Alcoholism, Clinical and Experimental Research·K BokströmG Långström
Jun 24, 1998·The Journal of Clinical Investigation·O F AlmeidaV K Patchev
May 25, 2001·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·M DriessenK Junghanns
May 2, 2003·Endocrine·Philip Barnett
Aug 19, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tom JohnstoneRichard J Davidson
Jun 20, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jennie R StevensonClyde W Hodge
Apr 1, 2009·Brain Research·George F Koob
Feb 13, 2010·Addiction Biology·Markus HeiligHoward C Becker
Jul 20, 2010·Drug and Alcohol Review·Jürgen RehmMichael Roerecke
Dec 3, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Herbert E CovingtonEric J Nestler
Apr 11, 2012·Pharmacology, Biochemistry, and Behavior·Glenn R Valdez, Erin Harshberger
Apr 3, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Amelie Soumier, Etienne Sibille
Jan 13, 2015·Biological Psychiatry·Tina M GrueneRebecca M Shansky
Mar 10, 2015·Nature Neuroscience·Kristen E PleilThomas L Kash
Apr 4, 2015·Neuropharmacology·Nikolaos KokrasChristina Dalla
Jun 7, 2015·Behavioural Brain Research·Kaziya M LeeKaren K Szumlinski
Sep 4, 2015·Alcoholism, Clinical and Experimental Research·Aaron WhiteRalph Hingson
Oct 20, 2015·American Journal of Preventive Medicine·Jeffrey J SacksRobert D Brewer
Jan 12, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Katherine M HolleranDanny G Winder
Mar 22, 2016·Cell Reports·Nicole A CrowleyThomas L Kash
May 27, 2016·Nature Reviews. Neuroscience·Joanna Urban-Ciecko, Alison L Barth
Aug 1, 2016·The Lancet. Psychiatry·George F Koob, Nora D Volkow
Aug 9, 2016·Pharmacology, Biochemistry, and Behavior·Brittany M PriddyLeandro F Vendruscolo
Aug 25, 2016·Nature·Catherine A MarcinkiewczThomas L Kash
Aug 25, 2016·Depression and Anxiety·Gaelle Douillard-GuillouxEtienne Sibille
Apr 4, 2017·Psychology of Addictive Behaviors : Journal of the Society of Psychologists in Addictive Behaviors·Cathryn Glanton Holzhauer, Stephanie A Gamble
Aug 15, 2017·Behavioral Neuroscience·José Colom-LapetinaRebecca M Shansky
Jan 29, 2018·Handbook of Experimental Pharmacology·Reginald CannadyPatrick J Mulholland
Mar 20, 2018·Journal of Visualized Experiments : JoVE·Jonathan T TingEd Lein
May 31, 2018·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sandra AhrensBo Li
Jun 17, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Oliver VranjkovicDanny G Winder
Jul 1, 2018·Neuropharmacology·Emily G Lowery-GiontaThomas Louis Kash
Aug 7, 2018·Alcoholism, Clinical and Experimental Research·Richard A GruczaLaura J Bierut

❮ Previous
Next ❯

Citations

Feb 2, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Bo JiangTetsuya Asakawa
Jun 12, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nigel C DaoNicole A Crowley
Jul 22, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Eva C Bach, Jeffrey L Weiner
Aug 4, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nicole A Crowley, Max E Joffe

❮ Previous
Next ❯

Software Mentioned

Graphpad Prism
EthoVision XT
Clampfit
ImageJ
EthoVison XT

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Brain Circuits in Emotional Learning

The neuronal circuits within the cortico-limbic brain regions form networks that mediate emotional behavior. Areas specific to emotional learning include the basal amygdala and sublenticular extended amygdala region along with a supplemental motor area. Discover the latest research on brain circuits in emotional learning here.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

© 2022 Meta ULC. All rights reserved