PMID: 19943456Dec 1, 2009Paper

Forced exercise improves passive avoidance memory in morphine-exposed rats

Pakistan Journal of Biological Sciences : PJBS
K SaadipourF Rahim

Abstract

The aim of this study was to investigate the effect of short-term forced exercise protocol on passive avoidance retention in morphine-exposed rats. Effects of morphine on acquisition and retrieval of retention have been proven in the avoidance paradigms. Twenty four male Wistar rats weighing 250-300 g were used in this study. Animals were randomly divided into four groups including: (1) non-morphine-exposed without exercise (nA.nE) (2) non-morphine-exposed with exercise (nA.E) (3) morphine-exposed without exercise (A.nE) and (4) morphine-exposed with exercise (A.E). Rats ran as forced exercise on the motorized treadmill 1 h daily for ten days. Morphine-exposed animals received intraperitoneal morphine during first 5 days of the exercise period and their dependence to morphine was confirmed by naloxane admistration (10 mg kg(-1), i.p.) and withdrawal test. After 10 days of forced exercise, step down latency was tested and Inflexion Ratio (IR) was evaluated in each rat. Baseline step down latencies before any morphine exposing or exercise have shown no significant alteration in all groups. Inflexion Ratio (IR) ofnA.E group has increased significantly (p<0.001) at 1, 3, 7 and 14 days after receiving shock (learning) compared to nA...Continue Reading

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Citations

May 28, 2011·Reviews in the Neurosciences·Adam StewartAllan V Kalueff
Apr 3, 2012·Journal of Bodywork and Movement Therapies·Habibollah Nemati KarimooyHabib Ollah Esmaily
Oct 24, 2012·Advances in Pharmacological Sciences·Sayede Maryam NaghibiAzita Aghaie
Sep 25, 2012·Brain Research Bulletin·Omar F KhabourMohammad A Alzubi
Feb 19, 2014·Physiology & Behavior·Mohammad NasehiMohammad-Reza Zarrindast
Jun 21, 2013·Asian Journal of Sports Medicine·Maryam RadahmadiNasrin Hosseini

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