Forced swim test-induced endocrine and immune changes in the rat: effect of subacute desipramine treatment

Pharmacology, Biochemistry, and Behavior
T J ConnorB E Leonard

Abstract

Previously it has been reported that forced swim test (FST) exposure activates the HPA-axis and produces alterations in both cellular and noncellular immunity in rats. Furthermore, there is evidence to suggest that pretreatment with antidepressants has a protective effect against FST-induced immune changes. The purpose of the present study was to examine the effect of subacute treatment with the tricyclic antidepressant desipramine (DMI, 5 and 10 mg/kg; I.P.) on immobility in the FST, and on FST-induced changes in endocrine and immune parameters in the rat. DMI treatment at a dose of 10 mg/kg produced a significant reduction in immobility time in the FST, while the 5 mg/kg dose was ineffective. FST exposure produced a significant increase in serum corticosterone and a decrease in adrenal ascorbic acid concentrations, neither of which were significantly attenuated by DMI pretreatment. There was a slight but nonsignificant suppression of PHA-induced lymphocyte proliferation 15 min post-FST exposure. However, DMI treatment produced a significant increase in lymphocyte proliferation at this time point. FST exposure caused a reduction in the percentage of lymphocytes and an increase in the percentage of neutrophils in the peripheral...Continue Reading

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Citations

May 27, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Matthew N Hill, Boris B Gorzalka
May 19, 2005·Pharmacology, Biochemistry, and Behavior·Kiran Babu SiripurapuGautam Palit
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