Forces associated with launch into space do not impact bone fracture healing

Life Sciences in Space Research
Paul ChildressMelissa A Kacena

Abstract

Segmental bone defects (SBDs) secondary to trauma invariably result in a prolonged recovery with an extended period of limited weight bearing on the affected limb. Soldiers sustaining blast injuries and civilians sustaining high energy trauma typify such a clinical scenario. These patients frequently sustain composite injuries with SBDs in concert with extensive soft tissue damage. For soft tissue injury resolution and skeletal reconstruction a patient may experience limited weight bearing for upwards of 6 months. Many small animal investigations have evaluated interventions for SBDs. While providing foundational information regarding the treatment of bone defects, these models do not simulate limited weight bearing conditions after injury. For example, mice ambulate immediately following anesthetic recovery, and in most cases are normally ambulating within 1-3 days post-surgery. Thus, investigations that combine disuse with bone healing may better test novel bone healing strategies. To remove weight bearing, we have designed a SBD rodent healing study in microgravity (µG) on the International Space Station (ISS) for the Rodent Research-4 (RR-4) Mission, which launched February 19, 2017 on SpaceX CRS-10 (Commercial Resupply Ser...Continue Reading

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Citations

Aug 8, 2019·Scientific Reports·Ushashi C DadwalMelissa A Kacena
Mar 14, 2021·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ushashi C DadwalMelissa A Kacena
Jul 2, 2021·Computational and Structural Biotechnology Journal·Nabarun ChakrabortyMelissa A Kacena
Aug 27, 2021·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Adam M KnoxChristopher D Collier

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