Forearm bone mineral density in postmenopausal women with rheumatoid arthritis

Calcified Tissue International
J IwamotoS Ichimura

Abstract

Osteoporosis in cases of rheumatoid arthritis (RA) is multifactorial, and the pathogenesis of bone loss induced by RA in postmenopausal women is not fully understood. The purpose of the present study was to determine the factors that affect forearm bone mineral density (BMD) in postmenopausal women with RA. In total, 839 postmenopausal women aged 46-90 years, were enrolled in the study; 470 patients with RA and 369 healthy controls (CON). Forearm (distal radius) BMD, measured by DXA using a DTX-200 (Osteometer, MediTech, CA, USA), was significantly lower in the RA group than in the CON group (P < 0.0001), even when adjusted for age, height, body weight, body mass index, and years since menopause (YSM) (P < 0.01). On multiple regression analysis, in the CON group, age and YSM were significantly correlated with BMD (P < 0.01 and P < 0.05, respectively). On the other hand, in the RA group, in addition to YSM, anatomic grade in the wrist, modified health assessment questionnaire (HAQ) score for the upper extremities, and erythrocyte sedimentation rate were each significantly correlated with BMD (P < 0.0001, P < 0.001, P < 0.0001, and P < 0.001, respectively), whereas functional class, duration of disease, dose of prednisolone used,...Continue Reading

Citations

Jun 19, 2010·International Orthopaedics·Akinobu NishimuraAkihiro Sudo
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Jun 19, 2007·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Santos CastañedaJ Alberto García-Vadillo
Nov 17, 2005·Rheumatic Diseases Clinics of North America·Glenn Haugeberg, Paul Emery
Oct 7, 2005·Arthritis and Rheumatism·Katja ThieleUNKNOWN German Collaborative Arthritis Centres
Nov 21, 2019·Calcified Tissue International·J IwamotoS Ichimura
Jul 2, 2020·Expert Opinion on Pharmacotherapy·Hennie G RatermanWillem F Lems
Jul 17, 2019·Arthritis Research & Therapy·T TomizawaS Matsuda

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