PMID: 9557926Apr 29, 1998Paper

Forearm vasorelaxation in hypertensive renal transplant patients: the impact of withdrawal of cyclosporine

Journal of Hypertension
M A van den DorpelA J Man in't Veld

Abstract

To determine whether cyclosporine A-induced hypertension in renal transplant recipients is accompanied by impairment of endothelium-dependent vasodilatation, which has been suggested by in-vitro and in-vivo animal experiments. In-vivo endothelium-dependent and endothelium-independent vasodilatation, and plasma concentrations of vasoactive hormones in 16 renal transplant patients were determined while they were being treated with cyclosporine A, and 16 weeks later, after their treatment had been changed to azathioprine therapy. The vasodilator response of the forearm vascular bed was measured by strain gauge venous occlusion plethysmography during intra-arterial infusion of acetylcholine (endothelium-dependent vasodilatation) and nitroprusside (endothelium-independent vasodilatation). Postischemic reactive flow was measured after 10 min of arterial occlusion. In addition, plasma concentrations of norepinephrine, and the prostanoids prostaglandin E2 and thromboxane B2, and also concentration of cyclosporine A in blood, were measured. Glomerular filtration rate and renal blood flow were estimated 1 day before the plethysmography study during each treatment period. Upon changing from cyclosporine A to azathioprine treatment, mean a...Continue Reading

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Citations

Nov 23, 2010·American Journal of Hypertension·Ilse P G BotdenEric J G Sijbrands
Feb 1, 2013·Transplantation·Dag Olav DahleAnders Asberg
Nov 4, 2006·Transplant International : Official Journal of the European Society for Organ Transplantation·Martin SilverbornAnders Jeppsson
Jun 12, 2010·Transplant International : Official Journal of the European Society for Organ Transplantation·Robinson JoannidesMichel Godin
Jun 8, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M J WilliamsR J Walker
Mar 18, 2000·Kidney International·S T MorrisA G Jardine

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