Forebrain noradrenaline and oral self-administration of ethanol by rats

Behavioural Brain Research
M E CorcoranH C Fibiger

Abstract

The effects of 6-hydroxydopamine-induced depletion of forebrain noradrenaline (NA) on oral intake of ethanol were studied in male Wistar rats. Prior depletion of NA produced a smaller and significantly less variable intake of a concentrated solution of ethanol than that of control rats, and this effect was not accompanied by hyperreactivity to aversive solutions of quinine. NA-depleted rats also displayed rejection 'thresholds' for ethanol solutions that were significantly lower than those of controls. Depletion of forebrain NA did not, however, affect the punishing effects of ethanol injections measured in the conditioned taste aversion paradigm. In contrast to these effects of NA depletion on initiation of ethanol intake, depletion of forebrain NA after a preference for ethanol had been established failed to affect subsequent intake of ethanol. These results suggest that forebrain NA is involved in the initiation of ethanol intake by naive rats but not in the maintenance of established patterns of intake by experienced rats. Possible mechanisms for this differential involvement of NA are discussed.

References

Jan 1, 1978·Annual Review of Pharmacology and Toxicology·H C Fibiger
Apr 1, 1979·Neuroscience Letters·S T MasonH C Fibiger
Jul 20, 1979·Brain Research·S T Mason, M E Corcoran
Nov 1, 1979·Pharmacology, Biochemistry, and Behavior·W M DavisS G Smith
Jul 1, 1978·Drug and Alcohol Dependence·J S Richardson, D M Novakovski
Sep 1, 1978·Physiology & Behavior·S T MasonH C Fibiger
Jun 1, 1978·Pharmacology, Biochemistry, and Behavior·J A Goas, A S Lippa
Sep 1, 1978·Pharmacology, Biochemistry, and Behavior·W M DavisT E Werner
Dec 1, 1976·Behavioral Biology·D M Feeney
Jul 1, 1973·Clinical Pharmacology and Therapeutics·S AhleniusP Södersten
May 1, 1971·Physiology & Behavior·J L Falk

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Citations

Jan 1, 1994·Journal of Neural Transmission. General Section·C J Clayton, R E Hicks
Jan 1, 1984·Alcohol·C M BeamanL D Reid
Dec 14, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·David Weinshenker, Jason P Schroeder
May 1, 1988·Drug and Alcohol Dependence·E L Rodríguez Echandía, M R Fóscolo
Jun 1, 1986·British Journal of Addiction·D Nutt, P Glue
Aug 16, 2005·Neuroscience and Biobehavioral Reviews·R Christopher Pierce, Vidhya Kumaresan
Jan 1, 1996·Addiction Biology·E P Noble

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