Forecasting Individual Patient Response to Radiation Therapy in Head and Neck Cancer With a Dynamic Carrying Capacity Model.

International Journal of Radiation Oncology, Biology, Physics
Mohammad U ZahidHeiko Enderling

Abstract

To model and predict individual patient responses to radiation therapy. We modeled tumor dynamics as logistic growth and the effect of radiation as a reduction in the tumor carrying capacity, motivated by the effect of radiation on the tumor microenvironment. The model was assessed on weekly tumor volume data collected for 2 independent cohorts of patients with head and neck cancer from the H. Lee Moffitt Cancer Center (MCC) and the MD Anderson Cancer Center (MDACC) who received 66 to 70 Gy in standard daily fractions or with accelerated fractionation. To predict response to radiation therapy for individual patients, we developed a new forecasting framework that combined the learned tumor growth rate and carrying capacity reduction fraction (δ) distribution with weekly measurements of tumor volume reduction for a given test patient to estimate δ, which was used to predict patient-specific outcomes. The model fit data from MCC with high accuracy with patient-specific δ and a fixed tumor growth rate across all patients. The model fit data from an independent cohort from MDACC with comparable accuracy using the tumor growth rate learned from the MCC cohort, showing transferability of the growth rate. The forecasting framework pred...Continue Reading

References

Jul 1, 1991·International Journal of Radiation Biology·G M TozerV J Cunningham
Jun 1, 1990·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J F Fowler
Aug 1, 1989·The British Journal of Radiology·J F Fowler
Mar 1, 1966·British Journal of Cancer·G G Steel, L F Lamerton
Apr 15, 1980·Cancer·D von FournierV Barth
Aug 13, 2002·Current Pharmaceutical Design·Eric J Friedman
Feb 18, 2004·International Journal of Radiation Oncology, Biology, Physics·Sandra DemariaSilvia C Formenti
Jan 1, 1950·Cancer·W J YOUDEN
Jun 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amit A LugadeEdith M Lord
Feb 15, 2008·Nature Reviews. Cancer·Alexander R A Anderson, Vito Quaranta
Feb 28, 2009·The Lancet Oncology·Stefan MichielsUNKNOWN MARCH and MACH-NC Collaborative Groups
Jul 4, 2009·The Lancet Oncology·Silvia C Formenti, Sandra Demaria
Jul 15, 2009·International Journal of Radiation Oncology, Biology, Physics·Alexei V ChvetsovRobert J Amdur
Sep 9, 2009·International Journal of Radiation Oncology, Biology, Physics·Steven A EschrichJavier F Torres-Roca
Sep 9, 2009·International Journal of Radiation Oncology, Biology, Physics·Steven EschrichJavier F Torres-Roca
Sep 16, 2009·Cancer Research·Robert A GatenbyThomas Vincent
Jul 27, 2010·Acta Biotheoretica·Heiko EnderlingPhilip Hahnfeldt
Jul 27, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Steven A EschrichJavier F Torres-Roca
Oct 20, 2012·International Journal of Radiation Oncology, Biology, Physics·Silvia C Formenti, Sandra Demaria
Jan 26, 2013·PloS One·Irina Kareva
Feb 11, 2014·Interface Focus·David Basanta, Alexander R A Anderson
Jan 1, 2014·Frontiers in Molecular Biosciences·Rajamanickam BaskarKheng-Wei Yeoh
Oct 21, 2015·Physics in Medicine and Biology·Alevei V ChvetsovRamesh Rengan
Nov 22, 2016·Molecular Cell·Toru Matsu-UraChristian I Hong
May 1, 2017·The Lancet Oncology·Jimmy J CaudellLouis B Harrison
Jun 7, 2017·Bulletin of Mathematical Biology·Kathleen P Wilkie, Philip Hahnfeldt
Mar 20, 2018·Cancer Growth and Metastasis·Kimberly M ArnoldJennifer Sims-Mourtada
Apr 10, 2018·Immunity·Vésteinn ThorssonIlya Shmulevich
Mar 5, 2019·International Journal of Radiation Biology·Enakshi D SunasseeHeiko Enderling
Apr 10, 2019·JCO Clinical Cancer Informatics·Juan Carlos López AlfonsoHeiko Enderling
Jun 13, 2019·Cancer Research·Bruna V Jardim-PerassiGary V Martinez
Jul 25, 2019·Bulletin of Mathematical Biology·Renee Brady, Heiko Enderling
Aug 20, 2019·Trends in Cancer·Heiko EnderlingLouis B Harrison
Oct 9, 2019·Physics in Medicine and Biology·Thomas D LewinHeiko Enderling

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.