PMID: 15359082Sep 11, 2004Paper

Forefront of Na+/Ca2+ exchanger studies: physiology and molecular biology of monovalent cation sensitivities in Na+/Ca2+ exchangers

Journal of Pharmacological Sciences
Akira UeharaIssei Imanaga

Abstract

Sensitivities of the reverse-mode Na+/Ca2+ exchange activity measured as the Na+i-dependent Ca2+ uptake to extracellular monovalent cations K+, Li+, and Na+ were compared between the K+ -dependent (NCKX2) and the K+ -independent Na+/Ca2+ exchanger (NCX1) overexpressed in a fibroblast cell. Interestingly, the exchange activity of NCKX2 was not influenced by Li+ while it was increased by K+. On the contrary, the activity of NCX1 was increased by Li+. Thus, the cation sensitivities to K+ and Li+ markedly differed between NCKX2 and NCX1. In addition, Na+ exerted a significantly smaller inhibitory effect on the activity in NCKX2 than in NCX1. The Na+/Ca2+ exchange activities of NCKX2 and NCX1 are considered to be regulated differentially via the respective binding site domains that have distinct sensitivities to the external monovalent cations.

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Citations

Jun 9, 2012·Cells, Tissues, Organs·Ping HuMichael L Paine
Apr 21, 2007·Annals of the New York Academy of Sciences·Ju-Young LeeSuk-Ho Lee
Apr 18, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Hui DongJonathan Lytton
May 29, 2018·Archives of Oral Biology·Hee-Eun Kim, Jeong Hee Hong

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