Foreign body granulomas after the use of dermal fillers: pathophysiology, clinical appearance, histologic features, and treatment

Archives of Plastic Surgery
Jeong Min Lee, Yu Jin Kim

Abstract

A foreign body granuloma is a non-allergic chronic inflammatory reaction that is mainly composed of multinucleated giant cells. Foreign body granulomas may occur after the administration of any dermal filler. Factors such as the volume of the injection, impurities present in the fillers, and the physical properties of fillers affect granuloma formation. The formation of granulomas involves five phases: protein adsorption, macrophage adhesion, macrophage fusion, and crosstalk. The clinical and pathologic features of granulomas vary depending on the type of filler that causes them. Foreign body granulomas can be treated effectively with intralesional corticosteroid injections. Surgical excisions of granulomas tend to be incomplete because granulomas have ill-defined borders and moreover, surgical excisions may leave scars and deformities.

References

Jan 6, 1992·Biochimica Et Biophysica Acta·R M TujebajevaG G Karpova
Jan 1, 1985·Aesthetic Plastic Surgery·L S CoopermanB B Pharriss
May 1, 1983·The Journal of Dermatologic Surgery and Oncology·N A SwansonA R Solomon
Jul 1, 1983·Journal of Clinical Pathology·G T Williams, W J Williams
Feb 1, 1983·Plastic and Reconstructive Surgery·B M Achauer
Sep 1, 1995·Plastic and Reconstructive Surgery·G LemperleM Lemperle
Apr 8, 1999·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·L S Baumann, F Kerdel
Jun 3, 1999·The British Journal of Dermatology·P SenetL Dubertret
Feb 26, 2000·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·J R Lupton, T S Alster
Jun 8, 2001·The American Journal of Dermatopathology·C RequenaL Requena
Sep 20, 2001·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·H HeiseP Heise
Jan 21, 2003·Archives of Dermatology·Eva-Maria ReisbergerWilhelm Stolz
Apr 25, 2003·The British Journal of Radiology·K T WongL T C Chow
Dec 3, 2003·Aesthetic Plastic Surgery·Gottfried LemperleUlrich Charrier
Apr 29, 2004·Plastic and Reconstructive Surgery·Dimitre Evstatiev
Feb 5, 2005·Journal of the American Academy of Dermatology·Meral J ArinNicolas Hunzelmann
Mar 5, 2005·Seminars in Cutaneous Medicine and Surgery·Ute S Zimmermann, Thierry J Clerici
Sep 2, 2005·International Journal of Dermatology·Yasemin Saray, A Tülin Güleç
Jan 18, 2006·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·P AndreU Zimmermann
Aug 29, 2006·Plastic and Reconstructive Surgery·Gottfried LemperleNelly Gauthier-Hazan
Sep 22, 2006·Journal of the European Academy of Dermatology and Venereology : JEADV·V Sanchez García, A Sanz Trelles
Apr 25, 2007·Annals of Plastic Surgery·M M Al-Qattan
May 24, 2007·The Journal of Dermatological Treatment·Markos AivaliotisNiki Zakopoulou
Nov 2, 2007·The Journal of Dermatology·Youhei UchidaTakuro Kanekura
Dec 29, 2007·Seminars in Immunology·James M AndersonDavid T Chang
Feb 12, 2008·The American Journal of Medicine·Thomas J Marrie
Mar 14, 2008·Veterinary Dermatology·Jacquelyn M WahlKeith E Murphy
May 1, 2006·Aesthetic Surgery Journal·Gottfried Lemperle, David M Duffy
May 6, 2009·Facial Plastic Surgery : FPS·Stuart H Bentkover
Jun 2, 2009·Plastic and Reconstructive Surgery·Gottfried LemperleDavid M Duffy
Jun 2, 2009·Plastic and Reconstructive Surgery·Gottfried Lemperle, Nelly Gauthier-Hazan
Sep 13, 2011·Aesthetic Plastic Surgery·Tae Hwan ParkChoong Hyun Chang
Nov 23, 2012·International Journal of Dermatology·Ji-Hye YangKee-Chan Moon
Jun 12, 2013·Nature Biotechnology·David W Grainger
Jul 5, 2013·Aesthetic Surgery Journal·Cemile Nurdan OzturkJames E Zins
Jan 29, 2014·Journal of the Korean Association of Oral and Maxillofacial Surgeons·Sang-Chang LeeTae-Geon Kwon

❮ Previous
Next ❯

Citations

Jul 1, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·D MerminM-S Doutre
Apr 6, 2017·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Jessica GandyChristopher Zachary
Mar 11, 2017·Plastic and Reconstructive Surgery. Global Open·Patrick MicheelsJoan Vandeputte
Dec 27, 2016·Plastic and Reconstructive Surgery. Global Open·Glynis Ablon
May 17, 2017·Current Opinion in Otolaryngology & Head and Neck Surgery·Leo L Wang, Oren Friedman
Jul 22, 2017·Archives of Plastic Surgery·Min ChoiJi Seon Cheon
Aug 29, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·C MenzerK Schaekel
Sep 16, 2017·Archives of Craniofacial Surgery·Kang Gyun ParkWoo Kyung Kim
Apr 6, 2018·Clinical Rheumatology·Olga Vera-LastraLuis J Jara
Apr 11, 2018·Plastic and Reconstructive Surgery. Global Open·Tahera Bhojani-Lynch
May 10, 2017·The Journal of Hand Surgery, European Volume·B T DingS Sechachalam
Dec 28, 2017·Imaging Science in Dentistry·Andre Luiz Ferreira CostaPaulo Henrique Braz-Silva
Dec 11, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·B P HiblerA M Rossi
Aug 31, 2018·Journal of Cosmetic Dermatology·Marcelo PompeuIzelda Maria Carvalho Costa
Sep 6, 2018·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·R Krzysztof MlosekSylwia Malinowska
Jun 23, 2018·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Carmen Pérez-RuizJulián Conejo-Mir Sánchez
Sep 28, 2017·Archives of Plastic Surgery·Seung Chul RheeRahil Hwang
Sep 10, 2019·Bio-medical Materials and Engineering·Atsuya WatanabeAntonella Schiavinato
Jan 10, 2019·Ophthalmic Plastic and Reconstructive Surgery·Shoaib Ugradar, Jonathan Hoenig
Oct 28, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·M BrolyO Cogrel
Jun 28, 2020·Journal of Cosmetic Dermatology·Hayson Chenyu WangXiaojun Wang
Oct 22, 2019·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Alayne LehmanGinny Vachon
Apr 18, 2020·Science Advances·Zhu ChengMatthew J Paszek
Mar 25, 2020·Aesthetic Plastic Surgery·Chenyu WangXiaojun Wang
May 31, 2018·Orbit·Mariel Angelou A ParulanUmashankar Ramachandran
Jul 19, 2017·Journal of Cosmetic Dermatology·Carlos Eduardo P AlcântaraRicardo A Mesquita
Apr 4, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Ramakanta LamichhaneHyun-Ju Jung
Apr 30, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·Ariadna Ortiz-BruguésCristina Carrera
Sep 4, 2019·Journal of Applied Biomaterials & Functional Materials·Cristian GuariseDevis Galesso
Nov 22, 2020·Journal of Cutaneous Pathology·Gabrielle BrodyBruce D Ragsdale
Dec 19, 2020·The American Journal of Dermatopathology·Elliot BlueStephanie Klein
Jan 19, 2021·Case Reports in Plastic Surgery & Hand Surgery·Narges HorriatAbelardo Medina
Mar 15, 2021·Archives of Craniofacial Surgery·Jin Woo Jang, Sang Yoon Kang
May 8, 2021·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Hwa Jung RyuJeong Eun Kim
May 23, 2021·Veterinary Medicine and Science·Ha-Jung KimYeong-Bin Baek
May 26, 2021·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Jun Ki HongBeom Joon Kim

❮ Previous
Next ❯

Software Mentioned

Aquamid

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete
E M RoiderJ Schauber
International Journal of Oral and Maxillofacial Surgery
N S Rajeevan, C S Soumithran
The British Journal of Oral & Maxillofacial Surgery
Christopher Avery, Nicholas Clifford
© 2021 Meta ULC. All rights reserved