PMID: 8963633Jan 1, 1996Paper

Foreign body reaction to exogenous pulmonary surfactant in an infant with hydrops and cardiomyopathy

Pediatric Pathology & Laboratory Medicine : Journal of the Society for Pediatric Pathology, Affiliated with the International Paediatric Pathology Association
R W BendonS Heffelfinger

Abstract

We present a hydropic infant who received exogenous surfactant and who had Noonan phenotype with hypertrophic cardiomyopathy. The infant had clinically diagnosed stridor for which bronchoscopy did not identify an origin. He died at 30 days of age. The bronchioles showed numerous eosinophilic plugs with a foreign body giant cell reaction. The plugs were positively immunostained with anti-aposurfactant protein B.

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