Forensic analysis of P2P derived amphetamine synthesis impurities: identification and characterization of indene by-products

Drug Testing and Analysis
John D PowerSimon D Brandt

Abstract

1-Phenyl-2-propanone (P2P) is an internationally monitored precursor that has become increasingly difficult for illicit amphetamine producers to source, which means that alternative routes to its preparation have become increasingly important. One such approach includes the hydrolysis of alpha-phenylacetoacetonitrile (APAAN) with sulfuric acid. Previously, we reported the identification of 4,6-dimethyl-3,5-diphenylpryid-2-one following implementation of hydrolysis conditions and it was proposed that this compound might serve as one route specific by-product in the APAAN to P2P conversion. This study continued to explore the presence of impurities formed during this conversion and expanded also into a second route of P2P synthesis starting from alpha-methylstyrene (AMS). All P2P products underwent the Leuckart procedure to probe the presence of P2P-related impurities that might have carried through to the final product. Two by-products associated with the APAAN hydrolysis route to P2P were identified as 2,3-diacetyl-2,3-diphenylsuccinonitrile (1) and 2-methyl-1-phenyl-1,3-dicarbonitrile-1H-indene (2), respectively. Two by-products associated with the AMS route to P2P and subsequent Leuckart reaction were 1,1,3-trimethyl-3-phenyl...Continue Reading

References

Jul 10, 2001·The Journal of Organic Chemistry·D Yang, C Zhang
Dec 1, 2001·Forensic Science International : Synergy·D BłachutK Wojtasiewicz

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Citations

Jan 20, 2017·Drug Testing and Analysis·Simon D Brandt, Pierce V Kavanagh
Jan 2, 2021·Forensic Science International : Synergy·Nicole S Jones, Jeffrey H Comparin
Aug 7, 2021·Drug Testing and Analysis·Deanna LangoneK Paul Kirkbride

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