Foretinib Enhances the Radiosensitivity in Esophageal Squamous Cell Carcinoma by Inhibiting Phosphorylation of c-Met

Journal of Cancer
Guangzong ChenXiao-Ning Zeng

Abstract

As a crucial event involved in the metastasis and relapse of esophageal cancer, c-Met overexpression has been considered as one of the culprits responsible for the failure in patients who received radiochemotherapy. Since c-Met has been confirmed to be pivotal for cell survival, proliferation and migration, little is known about its impact on the regulation of radiosensitivity in esophageal cancer. The present study investigated the radiosensitization effects of c-Met inhibitor foretinib in ECA-109 and TE-13 cell lines. Foretinib inhibited c-Met signaling in a dose-dependent manner resulting in decreases in the cell viability of ECA-109 and TE-13. Pretreatment with foretinib synergistically prompted cell apoptosis and G2/M arrest induced by irradiation. Moreover, decreases ability of DNA damage repair was also observed. In vivo studies confirmed that the combinatorial use of foretinib with irradiation significantly diminishes tumor burden compared to either treatment alone. The present findings implied a crucial role of c-Met in the modulation of radiosensitization in esophageal cancer, and foretinib increased the radiosensitivity in ECA-109 and TE-13 cells mainly via c-Met signaling, highlighting a novel profile of foretinib a...Continue Reading

Citations

Jun 20, 2018·Annals of the New York Academy of Sciences·Fazlur Rahman TalukdarZdenko Herceg
May 19, 2018·International Journal of Radiation Biology·Poushali BhattacharyaAmit Kumar
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Oct 30, 2020·Journal of Experimental Pharmacology·Haidar El DarsaOmar Abdel-Rahman
Mar 11, 2021·Cancer Chemotherapy and Pharmacology·Narges K GortanyMahmoud Ghazi-Khansari
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Jul 27, 2021·Frontiers in Cell and Developmental Biology·Yuyin FuJinliang Yang
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Methods Mentioned

BETA
flow cytometry
fluorescence microscopy
xenografts
xenograft

Software Mentioned

SPSS

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