Forkhead, a new cross regulator of metabolism and innate immunity downstream of TOR in Drosophila

Journal of Insect Physiology
Disha VarmaMichael Hoch

Abstract

Antimicrobial peptides (AMPs) are conserved cationic peptides which act both as defense molecules of the host immune system and as regulators of the commensal microbiome. Expression of AMPs is induced in response to infection by the Toll and Imd pathway. Under non-infected conditions, the transcription factor dFOXO directly regulates a set of AMP expression at low levels when nutrients are limited. Here we have analyzed whether target of rapamycin (TOR), another major regulator of growth and metabolism, also modulates AMP responses in Drosophila. We found that downregulation of TOR by feeding the drug rapamycin or by overexpressing the negative TOR regulators TSC1/TSC2, resulted in a specific induction of the AMPs Diptericin (Dpt) and Metchnikowin (Mtk). In contrast, overexpression of Rheb, which positively regulates TOR led to a repression of the two AMPs. Genetic and pharmacological experiments indicate that Dpt and Mtk activation is controlled by the transcription factor Forkhead (FKH), the founding member of the FoxO family. Shuttling of FKH from the cytoplasm to the nucleus is induced in the fat body and in the posterior midgut in response to TOR downregulation. The FKH-dependent induction of Dpt and Mtk can be triggered i...Continue Reading

References

Oct 10, 1995·Proceedings of the National Academy of Sciences of the United States of America·B LemaitreJ A Hoffmann
Aug 1, 1996·Mechanisms of Development·M Hoch, M J Pankratz
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·B LemaitreJ A Hoffmann
Jun 11, 1999·Genes & Development·A C GingrasN Sonenberg
Sep 20, 2001·Genes & Development·N Silverman, T Maniatis
Oct 25, 2001·Proceedings of the National Academy of Sciences of the United States of America·T OsterwalderH Keshishian
Aug 13, 2002·Nature Cell Biology·Ken InokiKun-Liang Guan
May 27, 2003·Nature Cell Biology·Hugo StockerErnst Hafen
Jan 5, 2007·Annual Review of Immunology·Bruno Lemaitre, Jules Hoffmann
Mar 30, 2011·Aging Cell·Cathy SlackLinda Partridge

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Citations

Feb 18, 2015·Fish & Shellfish Immunology·Haihong WangChunhua Jin
May 19, 2017·PloS One·Gerrit LochMichael Hoch
Jul 29, 2017·PLoS Neglected Tropical Diseases·Sarah M ShortGeorge Dimopoulos
Nov 1, 2017·Molecular and Cellular Biology·Laura Palanker MusselmanThomas J Baranski
Mar 27, 2019·Disease Models & Mechanisms·Jessica SharrockMarc S Dionne
Mar 25, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Saeideh DavoodiEdan Foley
Oct 29, 2019·The Journal of Animal Ecology·Fleur PontonStephen J Simpson
Dec 7, 2018·International Journal of Molecular Sciences·Ting LianMingyao Yang
Sep 6, 2020·Insect Science·Shuai BaiHongyu Zhang
Jan 17, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wei SunZe Zhang
Oct 7, 2020·The FEBS Journal·Catarina NunesTakashi Koyama
Aug 2, 2019·Ageing Research Reviews·Jacopo J V BrancaClaudio Nicoletti
Jan 29, 2021·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Shelley A Adamo
Feb 18, 2021·Proceedings of the National Academy of Sciences of the United States of America·Ekin BolukbasiLinda Partridge
May 16, 2021·Immunity & Ageing : I & a·Daniel K FabianJanet M Thornton

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