Forkhead Box F1 promotes breast cancer cell migration by upregulating lysyl oxidase and suppressing Smad2/3 signaling

BMC Cancer
Gisela Nilsson, Marie Kannius-Janson

Abstract

Epithelial-mesenchymal transition (EMT) increases cell migration and is implicated in cancer cell invasion and metastasis. We have previously described the involvement of the transcription factors, nuclear factor I-C2 (NFI-C2) and Forkhead box F1 (FoxF1), in the regulation of EMT and invasion during breast tumor progression. NFI-C2 counteracts these processes and FoxF1 is a directly repressed target of NFI-C2. FoxF1 induces EMT and invasiveness and enhances xenograft tumorigenicity in nude mice. Here we identify oppositely regulated targets of NFI-C2 and FoxF1 involved in these processes and further study a possible role for FoxF1 in tumorigenesis. We used Affymetrix microarray to detect changes in the transcriptome of a mouse mammary epithelial cell line upon overexpression of NFI-C2 or FoxF1. To elucidate the effects and signaling events following FoxF1 overexpression we investigated in vitro invasion capacity and changes in transcription and protein expression resulting from RNAi and inhibitor treatment. The extracellular matrix enzyme lysyl oxidase (LOX) was negatively regulated by NFI-C2 and positively regulated by FoxF1, and upregulation of LOX following FoxF1 overexpression in mouse mammary epithelial cells increased in ...Continue Reading

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Citations

Dec 31, 2016·International Journal of Molecular Sciences·Tong-Hong WangTzong-Ming Shieh
Aug 18, 2016·Oncotarget·Jinhua WangGuanhua Du
Jun 5, 2020·Journal of Receptor and Signal Transduction Research·Daoxin Jin, Fangfang Han
May 7, 2020·Cancer Metastasis Reviews·Yannasittha Jiramongkol, Eric W-F Lam

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Datasets Mentioned

BETA
GSE17636
GSE77551

Methods Mentioned

BETA
xenograft
electrophoresis
PCR
Protein Assay
FCS
flow cytometry
transfection

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