Forkhead box o as a sensor, mediator, and regulator of redox signaling

Antioxidants & Redox Signaling
Peter L J de KeizerTobias B Dansen

Abstract

The forkhead box O (FOXO) family of transcription factors regulates a variety of cellular programs, including cell cycle arrest, reactive oxygen species (ROS) scavenging, and apoptosis, and are of key importance in the decision over cell fate. In animal model systems it has been shown that FOXO is involved in the regulation of long lifespan. FOXO activity is tightly controlled by the insulin signaling pathway and by a multitude of ROS-induced posttranslational modifications. In the cell, ROS levels can be sensed by virtue of stimulatory and inhibitory oxidative modification of cysteine residues within proteins that control various signaling cascades. Recently, it was shown that cysteines in FOXO can also act as sensors of the local redox state. In this review we have outlined the cysteine-dependent redox switches that regulate both the insulin and ROS signaling pathways upstream of FOXO. Further, we describe how FOXO controls ROS levels by transcriptional regulation of a multilayered antioxidant system. Finally, we will discuss how cysteine-based redox signaling to FOXO could play a role in fine-tuning the optimal cellular response to ROS to control organismal lifespan.

References

Oct 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·M P CzechW S Lynn
Dec 2, 1993·Nature·C KenyonR Tabtiang
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·R M LebovitzM M Matzuk
Jul 10, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·E SchmidW Dröge
Aug 5, 2000·Free Radical Biology & Medicine·R Gopalakrishna, S Jaken
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·H S ParkE J Choi
Jan 12, 2001·Molecular and Cellular Biology·A H KimM V Chao
Mar 28, 2002·The Journal of Biological Chemistry·Seung-Rock LeeSue Goo Rhee
Sep 20, 2002·Nature·Geert J P L KopsBoudewijn M T Burgering
Nov 6, 2002·The Journal of Biological Chemistry·Yong Hee LeeMorris F White
Jan 9, 2003·Structure·Xin HuangXiaotian Zhu
Apr 12, 2003·Science·Siu Sylvia LeeGary Ruvkun
Apr 26, 2003·Science·George Georgiou, Lluis Masip
Apr 26, 2003·Science·Zachary A WoodP Andrew Karplus
Jul 1, 1956·Journal of Gerontology·D HARMAN
Oct 3, 2003·The Journal of Biological Chemistry·Hiroaki MurataTakahito Kondo
Oct 17, 2003·The Journal of Physiology·Julio F Turrens
Jan 28, 2004·Annual Review of Pharmacology and Toxicology·Leslie B PooleAl Claiborne
May 8, 2004·Mechanisms of Ageing and Development·Jingtao SunJohn Tower
May 14, 2004·The Biochemical Journal·Janet V Cross, Dennis J Templeton
Sep 15, 2004·The Journal of Biological Chemistry·Miklós Geiszt, Thomas L Leto
Nov 13, 2004·The EMBO Journal·Marieke A G EssersBoudewijn M T Burgering
Dec 14, 2004·The Journal of Biological Chemistry·Hyun Ae WooSue Goo Rhee
Jan 26, 2005·Proceedings of the National Academy of Sciences of the United States of America·Haojie HuangDonald J Tindall
Mar 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Seung Wook OhHeidi A Tissenbaum
Jun 16, 2005·The Biochemical Journal·Anne-Cécile V BayneRajindar S Sohal
Jul 13, 2005·The Journal of Cell Biology·Jun SunayamaYukiko Gotoh
Oct 18, 2005·Biochimica Et Biophysica Acta·Zhong-Yin Zhang
Oct 28, 2006·Experimental Gerontology·James R CypserThomas E Johnson
Nov 23, 2006·Cellular Signalling·Sachie AsadaAkiyoshi Fukamizu

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Citations

Mar 16, 2011·Current Osteoporosis Reports·Stavroula Kousteni
Mar 16, 2013·Cell Death & Disease·Kui WangYuquan Wei
Jan 5, 2011·Antioxidants & Redox Signaling·Regina Brigelius-Flohé, Leopold Flohé
Jan 18, 2011·Antioxidants & Redox Signaling·Anna A Szypowska, Boudewijn M T Burgering
Aug 21, 2012·Antioxidants & Redox Signaling·Dolors SerraLaura Herrero
Mar 6, 2013·Antioxidants & Redox Signaling·William C OrrRajindar S Sohal
Nov 14, 2012·Antioxidants & Redox Signaling·Matteo Parri, Paola Chiarugi
Mar 29, 2012·Experimental Diabetes Research·Bhaskar PonugotiDana T Graves
Nov 19, 2013·PloS One·Christiaan F LabuschagneArjan B Brenkman
Jan 26, 2013·International Journal of Molecular Sciences·Senthilkumar Kalimuthu, Kim Se-Kwon
May 2, 2014·Nature Communications·Shoshana M BartellMaria Almeida
Sep 30, 2014·Nature Communications·Catalina Romero-AristizabalJavier Apfeld
Jan 24, 2014·Antioxidants & Redox Signaling·Emilio SiendonesPlácido Navas
May 18, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Hiroshi ShigetomiHiroshi Kobayashi
Jul 13, 2011·The Journal of Cell Biology·Toren Finkel
Jan 27, 2016·Molecules and Cells·Marrit Putker, John Stuart O'Neill
Aug 1, 2012·The Journal of Physiology·Lorenza BroccaMaria Antonietta Pellegrino
Dec 19, 2012·Trends in Endocrinology and Metabolism : TEM·Ana Ortega-Molina, Manuel Serrano
Jul 24, 2012·Biochemical and Biophysical Research Communications·Chae Young HwangKi-Sun Kwon
Nov 15, 2011·Free Radical Biology & Medicine·Rajindar S Sohal, William C Orr
Nov 29, 2013·The Journal of Investigative Dermatology·Juewon KimTae R Lee
Sep 4, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Ana P CappelliEverardo M Carneiro
Feb 18, 2014·Biochimica Et Biophysica Acta·Marcus W SteppIgor N Zelko
Jun 27, 2014·Oxidative Medicine and Cellular Longevity·Nancy P Gómez-CrisóstomoSelva Rivas-Arancibia
Sep 12, 2012·Experimental Gerontology·Alexandra S Bause, Marcia C Haigis
Aug 12, 2014·Biochemical Society Transactions·Marrit PutkerTobias B Dansen
Apr 20, 2016·Antioxidants & Redox Signaling·Susanna BoronatElena Hidalgo
Dec 18, 2013·Mitochondrion·Neelu Yadav, Dhyan Chandra
Mar 29, 2014·Oxidative Medicine and Cellular Longevity·Ying-Na LiXu-Jun Qin
Jan 22, 2013·Molecular Cell·Marrit PutkerTobias B Dansen
Aug 9, 2011·Free Radical Biology & Medicine·Ekta Jindal, Shyamal K Goswami
Oct 12, 2012·Cell Transplantation·Ah-Young KimKyu-Shik Jeong
Apr 11, 2018·Antioxidants & Redox Signaling·David YoungJoris Messens
Aug 30, 2017·Proceedings of the National Academy of Sciences of the United States of America·Xiao-Shuai ZhangWei-Hua Xu
Aug 2, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Sai-Chuen FuLeung-Kim Hung
Apr 28, 2012·Circulation Research·Mark F Oellerich, Michael Potente
Nov 22, 2018·Free Radical Research·Jie WuZhongqing Chen

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Methods Mentioned

BETA
acetylation
nuclear translocation
GTPase

Related Concepts

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