Form and function of the Golgi apparatus: scaffolds, cytoskeleton and signalling

FEBS Letters
Prajakta Kulkarni-GosaviPaul A Gleeson

Abstract

In addition to the classical functions of the Golgi in membrane transport and glycosylation, the Golgi apparatus of mammalian cells is now recognised to contribute to the regulation of a range of cellular processes, including mitosis, DNA repair, stress responses, autophagy, apoptosis and inflammation. These processes are often mediated, either directly or indirectly, by membrane scaffold molecules, such as golgins and GRASPs which are located on Golgi membranes. In many cases, these scaffold molecules also link the actin and microtubule cytoskeleton and influence Golgi morphology. An emerging theme is a strong relationship between the morphology of the Golgi and regulation of a variety of signalling pathways. Here, we review the molecular regulation of the morphology of the Golgi, especially the role of the golgins and other scaffolds in the interaction with the microtubule and actin networks. In addition, we discuss the impact of the modulation of the Golgi ribbon in various diseases, such as neurodegeneration and cancer, to the pathology of disease.

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Citations

Sep 10, 2019·FEBS Letters·Maria Antonietta De MatteisAlberto Luini
May 16, 2020·Biology of Reproduction·Przemysław ZakrzewskiMarta Lenartowska
Apr 23, 2020·Human Reproduction Update·Christiane PleugerMoira K O'Bryan
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Feb 1, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Xiao HeLiming Zhang
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Aug 20, 2020·Chemical Reviews·Hongjian HeBing Xu
Jun 1, 2021·Frontiers in Cell and Developmental Biology·Xiaoyan Zhang
Jun 8, 2021·Frontiers in Cell and Developmental Biology·Ping-Shuang LuShao-Chen Sun
Jun 17, 2021·Biology of Reproduction·Wenfeng XiongZhugang Wang
Sep 1, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Manyue ZhangPeng Zhang

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