Formal asymmetric enone aminohydroxylation: organocatalytic one-pot synthesis of 4,5-disubstituted oxazolidinones

Chemical Communications : Chem Comm
David Cruz CruzKarl Anker Jørgensen

Abstract

A formal asymmetric organocatalytic aminohydroxylation reaction of enones has been achieved via an aziridination-double S(N)2 sequence. As a part of the reaction design, the generated amino alcohol products are isolated as the corresponding oxazolidinones in good yields and excellent stereoselectivities.

References

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