Formaldehyde exposure and asthma in children: a systematic review

Environmental Health Perspectives
Gerald McGwinJohn I Kennedy


Despite multiple published studies regarding the association between formaldehyde exposure and childhood asthma, a consistent association has not been identified. Here we report the results of a systematic review of published literature in order to provide a more comprehensive picture of this relationship. After a comprehensive literature search, we identified seven peer-reviewed studies providing quantitative results regarding the association between formaldehyde exposure and asthma in children. Studies were heterogeneous with respect to the definition of asthma (e.g., self-report, physician diagnosis). Most of the studies were cross-sectional. For each study, an odds ratio (OR) and 95% confidence interval (CI) for asthma were either abstracted from published results or calculated based on the data provided. Characteristics regarding the study design and population were also abstracted. We used fixed- and random-effects models to calculate pooled ORs and 95% CIs; measures of heterogeneity were also calculated. A fixed-effects model produced an OR of 1.03 (95% CI, 1.021.04), and random effects model produced an OR of 1.17 (95% CI, 1.011.36), both reflecting an increase of 10 microg/m3 of formaldehyde. Both the Q and I2 statisti...Continue Reading


Sep 1, 1991·British Journal of Industrial Medicine·P SymingtonS Holgate
Aug 1, 1990·Environmental Research·M KrzyzanowskiM D Lebowitz
Mar 1, 1996·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·F WantkeR Jarisch
Jan 1, 1997·International Archives of Occupational and Environmental Health·G WieslanderG Boman
Feb 21, 1997·Journal of Toxicology and Environmental Health·D PaustenbachS B Horowitz
Jan 7, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G SmedjeC Edling
May 12, 2000·American Journal of Respiratory and Critical Care Medicine·P FranklinS Stick
Sep 6, 2002·The European Respiratory Journal·K B RumchevS M Stick
Feb 6, 2003·The Journal of Clinical Investigation·Jack A EliasZhou Zhu
Apr 5, 2003·Environmental Health Perspectives·Ralph J DelfinoYe Hu
Mar 9, 2006·The Journal of Allergy and Clinical Immunology·Gaël TavernierRobert Niven
Oct 15, 2008·Toxicology and Applied Pharmacology·Chad M ThompsonRoland C Grafström
Jan 2, 2009·Pediatrics·William P Meehan, Richard G Bachur
Apr 16, 2009·Pediatrics·Lara J AkinbamiEdward J Sondik

❮ Previous
Next ❯


Apr 4, 2014·Environmental Health Perspectives·Alessandro MarconRoberto de Marco
Dec 7, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Julia E RagerRebecca C Fry
Nov 17, 2010·Environmental Health : a Global Access Science Source·William J FiskMark J Mendell
Aug 4, 2011·Environmental Health Perspectives·Célina RodaIsabelle Momas
Jan 17, 2013·Environmental Health Perspectives·Julia E RagerRebecca C Fry
Nov 10, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Chad M Thompson, Roland C Grafström
Feb 6, 2016·International Journal of Environmental Research and Public Health·Nicole Bijlsma, Marc M Cohen
Sep 6, 2011·International Journal of Hygiene and Environmental Health·Pierre Le CannBarbara Le Bot
Dec 8, 2009·Toxicology Letters·Chad M ThompsonRoland C Grafström
Jul 15, 2015·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Judy S LaKindDonald R Mattison
Jun 11, 2014·Critical Reviews in Food Science and Nutrition·Saeed Akhtar
Oct 31, 2014·Environmental Health : a Global Access Science Source·Gregg P MaceyDavid O Carpenter
Jul 29, 2016·Environmental Science and Pollution Research International·Joana MadureiraEduardo de Oliveira Fernandes
Sep 21, 2016·Journal of Toxicology and Environmental Health. Part a·Joana MadureiraEduardo de Oliveira Fernandes
Jul 28, 2016·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Xin TongWen H Shen
Dec 3, 2016·Scientific Reports·Johanna M GostnerFlorian Überall
Jan 5, 2017·Allergy·J GenuneitUNKNOWN Task Force ‘Overview of Systematic Reviews in Allergy Epidemiology (OSRAE)’ of the EAACI Interest Group on Epidemiology
May 10, 2017·Journal of Occupational and Environmental Medicine·Ritsuko Arakawa SuzukiHajime Kurosawa
Nov 22, 2017·Particle and Fibre Toxicology·Kirsty MeldrumMartin O Leonard
Oct 23, 2012·Nurse Educator·Anita D Savell, Barbara Sattler
Oct 11, 2014·Environmental Health Perspectives·Watcharoot KanchongkittiphonWanda Phipatanakul
Sep 1, 2017·Journal of the American Heart Association·Hanan QasimFatima Z Alshbool
Oct 11, 2012·Environmental Toxicology·Daniel J HochmanEdward G Brooks
Nov 24, 2011·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Ki-Hyun KimJong-Tae Lee
Apr 9, 2019·American Journal of Respiratory and Critical Care Medicine·Dong Keon YonMan Yong Han
Aug 9, 2019·Expert Review of Anti-infective Therapy·Philip NikolicJohn Whitehall
Nov 18, 2014·Expert Review of Clinical Immunology·Nara Tagiyeva, Aziz Sheikh
Jan 23, 2020·International Journal of Molecular Sciences·Anna Merecz-SadowskaRadoslaw Zajdel
Mar 8, 2020·International Journal of Environmental Research and Public Health·Giulia SquillaciotiRoberto Bono
Aug 19, 2016·The British Journal of Dermatology·J KimK Ahn

❮ Previous
Next ❯

Related Concepts

Related Feeds


This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.