Formaldehyde-induced histone H3 phosphorylation via JNK and the expression of proto-oncogenes

Mutation Research
Ikuma Yoshida, Yuko Ibuki

Abstract

Formaldehyde (FA) is a very reactive compound that forms DNA adducts and DNA-protein crosslinks, which are known to contribute to FA-induced mutations and carcinogenesis. Post-translational modifications to histones have recently attracted attention due to their link with cancer. In the present study, we examined histone modifications following a treatment with FA. FA significantly phosphorylated histone H3 at serine 10 (H3S10), and at serine 28 (H3S28), the time-course of which was similar to the phosphorylation of H2AX at serine 139 (γ-H2AX), a marker of DNA double strand breaks. The temporal deacetylation of H3 was observed due to the reaction of FA with the lysine residues of histones. The phosphorylation mechanism was then analyzed by focusing on H3S10. The nuclear distribution of the phosphorylation of H3S10 and γ-H2AX did not overlap, and the phosphorylation of H3S10 could not be suppressed with an inhibitor of ATM/ATR, suggesting that the phosphorylation of H3S10 was independent of the DNA damage response. ERK and JNK in the MAPK pathways were phosphorylated by the treatment with FA, in which the JNK pathway was the main target for phosphorylation. The phosphorylation of H3S10 increased at the promoter regions of c-fos ...Continue Reading

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Citations

Jul 29, 2016·Microbiology and Molecular Biology Reviews : MMBR·András ZekeMarie A Bogoyevitch
Dec 8, 2017·Journal of Cellular Physiology·Shu-Jie HuangAndy T Y Lau
Jun 17, 2020·Archives of Toxicology·Andrea HartwigGerhard Eisenbrand
Mar 4, 2021·Environmental Science and Pollution Research International·Rui YanAndy T Y Lau
Mar 12, 2021·Current Pain and Headache Reports·Mayank ArankeJared Herman
May 12, 2021·Journal of Cellular and Molecular Medicine·Ying ZhangZhirong Jiang

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